Understand Mechanisms of Oligodendrocyte
Il y a 4 mois
**Understand mechanisms of oligodendrocyte differentiation to treat multiple sclerosis.**:
- Réf **ABG-125757**
- Stage master 2 / Ingénieur- Durée 6 mois- Salaire net mensuel 600- 10/09/2024- IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire CERBM - GIE- Lieu de travail- Strasbourg/Illkirch Grand Est France- Champs scientifiques- Biologie
- Psychologie, neurosciences
- Mots clés- oligodendrocyte, differentiation, transcritional control, multiple sclerosis**Établissement recruteur**:
**Site web**:
- The project will be carried out at the IGBMC (Strasbourg-Illkirch), an international research institute located in the heart of a dynamic research region at the crossroads of France, Germany and Switzerland. It will benefit from state-of-the-art infrastructures, technical platforms and their expertise, as well as ongoing local and international collaborations.**Description**:
- Oligodendrocytes are neural cells providing structural and molecular support essential for development and functions of the nervous system. They are endowed with a capacity of regeneration which, when compromised, leads to a number of neurodegenerative disorders including multiple sclerosis (MS). Retinoid X receptor gamma (RXRg) is a master regulator of several hormonal signaling pathways and a key positive regulator of oligodendrocyte differentiation during the regeneration process in MS and during development. The objective of the project will be to investigate mechanisms of such activities by reconstructing RXRg-dependent transcriptional programs in oligodendrocyte differentiation (sequence of gene activation with determination of regulatory hubs). The relevance of a newly discovered genes in such regulations will be tested experimentally by pharmacological or Crispr Cas9 dependent modulations in primary cultures of mouse neural-stem-cell-derived oligodendrocyte progenitors in vitro. This work should allow to identify new molecular players in differentiation of oligodendrocytes which might be of direct relevance for treatment of multiple sclerosis. Such relevance could be tested in a follow-up PhD project.- Relevant references from the team:
- DOI: 10.1038/nn.2702- DOI: 10.1016/j.scr.2019.101443- DOI: 10.3390/nu13030925**Profil**:
**Prise de fonction**:
- Dès que possible
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