Postdoctoral Position On Fgfr3-related Disorders
il y a 7 jours
**About us**:
The _Imagine_ Institute (IHU, ‘Institut Hospitalo-Universitaire’, INSERM U1163) is a recent research structure located within Necker Children’s Hospital (Paris).
Its research labs are focused on understanding the molecular mechanisms of genetic diseases that affect the adaptive and innate immune systems, the skeletal dysplasia, the nervous system, stem cell differentiation, kidney physiology, metabolism, etc.
- Imagine_ offers a unique environment in which clinical and basic science synergize to produce astonishing contributions in areas as diverse as osteochondrodysplasia, immunology, molecular genetics, cell biology, and clinical and translational research.
- Imagine_ is internationally recognized ensuring high-quality, well-published, multi-disciplinary research.
**Mission**:
**Presentation**:
A postdoctoral position is available in the laboratory of Molecular and physiopathological bases of osteochondrodysplasia, led by Dr Laurence Legeai-Mallet, to define the impact of FGFR3 signaling alterations on bone functions and premature aging.
The laboratory studies rare skeletal disorders affecting bone and/or cartilage formation from early embryonic development until adulthood. The team is conducting pre-clinical studies to test and identify drugs able to correct long bone growth plate, craniofacial and spine anomalies in FGFR3-related animal models.
**Project**:
The project is designed to define the cellular and molecular regulatory pathways involved in these effects, to decipher the complexity of multi-systemic impairments in FGFR3-associated disorders and to the development novel potent therapeutic approaches for adult FGFR3-related patients and premature bone aging.
**Characterize the impact of FGFR3 mutation in skeleton, bone repair and aging.** The objective is to explore the functional impact of Fgfr3N534K/+ mutation on bone physiology, repair and aging using mouse models of ubiquitous or bone selective expression of this mutation. To this end, it will perform deep bone phenotyping approaches paired with molecular, morphometric studies to understand the ageing-associated bone pathologies in this monogenic disorder associated with early onset osteoporosis.
**Investigate the therapeutic potential of FGFR3 antagonists in bone disorders and premature aging.** Using Fgfr3N534K/+ adult animals, our preliminary data suggest that subcutaneous administration of FGFR3 antagonists modified the balance bone formation/bone remodeling. The objective is to better define the mechanisms of action of FGFR3 antagonists, to screen novel potent drugs and to test their therapeutic potential on osteochondrodysplasia and bone premature aging.
**Profile**:
**Contract**: The position is offered for two years with salary depending on experience
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