Impact of Apoe4 On Synaptic Degeneration in

il y a 1 mois


Marseille, France Institut de Neurophysiopathologie Temps plein

**Impact of ApoE4 on synaptic degeneration in Alzheimer's disease**:

- Réf
- **ABG-111437**
- Sujet de Thèse- 24/02/2023- Financement public/privé- Institut de Neurophysiopathologie- Lieu de travail- MARSEILLE - Provence-Alpes-Côte d'Azur - France- Intitulé du sujet- Impact of ApoE4 on synaptic degeneration in Alzheimer's disease- Champs scientifiques- Psychologie, neurosciences
- Biologie
- Santé, médecine humaine, vétérinaire
- Mots clés- Alzheimer's disease, Synaptic degeneration**Description du sujet**:

- Alzheimer’s disease (AD) is one of the biggest scientific and socio-economic challenges of the 21st century. Currently, there is no cure. Aggregates of amyloid-β and tau protein, along with neuroinflammation/gliosis, are hallmarks of AD that lead to synaptic and neuronal loss as the basis for cognitive decline. The latter correlates closely with the brain distribution of tau aggregates, providing a strong incentive to investigate a link between tau accumulation and synaptic degeneration.- Brain apolipoprotein E (ApoE), mainly produced by astrocytes, is essential for lipid transport to neurons and synaptic functions. ApoE4 isoform is the strongest genetic risk factor for AD and contributes to tau-mediated neurodegeneration. Determining how ApoE4 controls tau-mediated synaptic degeneration is thus essential to understand AD and develop efficient treatments, yet this requires fine characterization of ApoE4 functions at tau-damaged synapses with a synaptic resolution.-
**Prise de fonction**:

- 02/10/2023**Nature du financement**:

- Financement public/privé**Précisions sur le financement**:

- A*MIDEX**Présentation établissement et labo d'accueil**:

- Institut de Neurophysiopathologie- The INP is a center of training and research that combines basic and translational research to study the organization, function and interaction of neural cells, as well as the molecular and cellular basis of major brain diseases. The INP is part of the Centre of Excellence in Neurodegeneration (CoEN) and offers an internationally competitive research environment with state-of-the-art facilities. The PhD student will be supervised by Dr. Maud Gratuze. The project will be developed at the Faculty of Medicine, located in the centre of Marseille, a few kilometers from the magnificent seafront, the Calanques National Park and the charm of inland Provence, all ideally suited to outdoor and cultural activities.**Site web**:
**Intitulé du doctorat**:

- Doctorat de neurosciences**Pays d'obtention du doctorat**:

- France**Etablissement délivrant le doctorat**:

- Aix-Marseille Université**Ecole doctorale**:

- Sciences de la vie et de la santé-
- Preferable: comfortable with mouse handling- **SOFT SKILLS **Autonomy, work ethic, critical thinking, adaptability, teamwork, motivation, curiosity, problem-solving- 30/04/2023



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