A permanent position of research fellow at INRAE

Junior research scientist on the trafficking of macromolecules of plant viruses34000 MONTPELLIERA permanent position of research fellow at INRAE (CRCN) on trafficking of viral macromolecules withinhost plants is open for the 2025 competition campaign, in the group of Stéphane Blanc (MULTI) at the Plant Health Institute of Montpellier (PHIM), France.For more information, please consult the position profile on the INRAE website: https://jobs.inrae.fr/en/open-competitionsThe French National Research Institute for Agriculture, Food, and Environment (INRAE) is a major player globally in research and innovation. Gathering a community of 12,000 people with 272 units including fundamental and experimental research, spread out throughout 18 regional centres in France.Internationally, INRAE is among the top research organisations in agricultural and food sciences, plant and animal sciences, as well as in ecology and environmental science. It is the world’s leading research organisation specialising in agriculture, food and the environment.Faced with a growing world population, climate change, the depletion of resources and declining biodiversity, the Institute has a major role to play in providing the knowledge base supporting the necessary acceleration of agricultural, food and environmental transitions, to address the major global challenges.INRAE is recruiting researchers by open competitionand offering permanent position.Work environment, missions and activitiesThe Plant Health Institute of Montpellier (PHIM) conducts research on plant health, focusing particularly on plant-microorganism and bioaggressor interactions (viruses, bacteria, fungi, nematodes, insects). You will join the MULTI team, whose thematic is the study of the biology of multi-component viral systems. The host team recently demonstrated the existence of a multicellular lifestyle in multipartite viruses (Nanovirus model), where the viral genome operates with its different genomic segments located in distinct host cells. This phenomenon is made possible by the exchange of gene expression products between cells, allowing functional complementation at supracellular level. The impact of this discovery is considerable: it introduces a new perspective in the study of viruses, now possibly considered as biological entities also capable of unsuspected intercellular interactions. To go further, you will need to identify and characterize the gene expression products (mRNAs and/or proteins) that traffic between cells and over long distances, the underlying molecular mechanisms, and their regulation. Your main mission will be to elucidate these questions and thus contribute to advancing the understanding of this newly discovered multicellularity in viruses. In the longer term, the project may extend to viruses other than those studied by the team to establish a functional map of the trafficking of viral gene expression products. The challenge will be to understand the heterogeneity that exists in the expressed viral functions depending on the cells/tissues/organs colonized with different combinations of these gene expression products. For example, specific trafficking of the expression products of different viral genes could differentially functionalize the cells/tissues/organs of the infected host, inducing local specialization/differentiation whose orchestration would allow host infection. This concept has been barely explored, if at all, in virology. It should represent a new research theme at PHIM, offering you a particularly interesting perspective for autonomy and career development.The research scientist position will require working in a restricted access zone (ZRR), which necessitates an access authorization request.Training and skillsPhD or equivalentCompetition open to candidates with a PhD (or equivalent). Desired training and skills include plant physiology, virology, cell biology, molecular biology. Extensvie experience in cellular imaging, including in vivo approaches, is highly recommended. Originality and creativity in previous work are key criteria for the host team. Candidates should have a good command of English (both written and spoken), and long-term international experience would also be desirable. Successful candidates who have not yet acquired this experience abroad will be required to do so after their probationary period (1st year). #J-18808-Ljbffr