Postdoctoral Researcher

Organisation/Company CNRS Department Centre de Biophysique Moléculaire Research Field Chemistry Biological sciences Pharmacological sciences Researcher Profile Recognised Researcher (R2) Application Deadline 9 Oct 2026 - 23:59 (UTC) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Dec 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The main mission of the postdoctoral researcher will be to develop, optimize and apply advanced mass spectrometry approaches for the structural and molecular characterization of ARDCs, and to analyze and interpret the resulting data.

• Develop and optimize mass spectrometry methodologies for the structural characterization of ARDCs.
• Characterize the integrity and molecular mass of ARDCs using intact mass spectrometry approaches under both denaturing and native conditions.
• Determine the Drug-to-Antibody Ratio (DAR) and characterize the Drug Load Distribution (DLD), when required.
• Apply, when appropriate, bottom-up, middle-up/middle-down and top-down strategies for in-depth molecular characterization of ARDCs.
• Develop and perform upstream biochemical treatments, including deglycosylation and disulfide bond reduction.
• Identify and characterize antibody modifications induced by conjugation.
• Investigate the impact of conjugation on antibody structure and conformation, notably using ion mobility mass spectrometry and Collision Induced Unfolding (CIU) approaches.
• Complement the characterization of ARDCs using chromatographic and biophysical approaches, including HIC, SEC-MALS and DLS, to assess their hydrophobicity, aggregation state and degree of multimerization.
• Process, analyze and interpret mass spectrometry data and complementary analytical data.
• Assess the performance and limitations of the different approaches and propose methodological improvements.
• Participate in scientific discussions with the different project partners.
• Contribute to the preparation of scientific publications, reports, and presentations.
• Present results at project meetings, seminars, and scientific conferences.
• Maintain scientific awareness of developments in the fields of protein mass spectrometry, antibody characterization and therapeutic bioconjugates.

The Center for Molecular Biophysics (CBM) is a CNRS research institute comprising approximately 160 staff members. CBM develops interdisciplinary research at the interface of chemistry, biology, and physics, with a focus on understanding the molecular mechanisms of life and the dysfunctions leading to disease development.

The postdoctoral researcher will be recruited at the Centre de Biophysique Moléculaire (CBM, CNRS, Orléans) as part of a research project dedicated to the development and characterization of Antibody-Radionuclide-Drug Conjugates (ARDCs). ARDCs represent a new generation of therapeutic agents combining the targeting specificity of monoclonal antibodies with the complementary action of a radionuclide and a drug molecule. Their development requires advanced analytical approaches to accurately characterize antibody integrity, the extent of conjugation, and potential structural modifications induced by conjugation.

The postdoctoral researcher will join the MO²VING platform and will be under the direct supervision of the platform manager. The successful candidate will interact closely with platform staff, research teams within the laboratory, and external partners.

Employment Conditions and Benefits

• Full-time position: 38.5 hours per week.
• 44 days of annual leave per year.
• On-site subsidized staff restaurant.
• Employer contribution of 75% toward public transportation subscriptions.
• Sustainable mobility allowance
• Sports and recreational activities organized by the local social action committee.
• Campus childcare and leisure facilities.
• Additional CNRS employee benefits.

Education and experience

• PhD in analytical chemistry, biochemistry, chemistry, structural biology, protein science or a related discipline.
• Experience in structural mass spectrometry, particularly HRMS, LC-MS, native MS, intact mass or top-down MS, would be highly desirable. &lt