M/F Research Scientist in Microbiology

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France, Auvergne-Rhône-Alpes EuroSoHo Temps plein

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Organisation/Company CNRS Department Biotechnologie et signalisation cellulaire Research Field Chemistry Physics » Biophysics Biological sciences » Biological engineering Researcher Profile Recognised Researcher (R2) Application Deadline 2 Oct 2026 - 23:59 (UTC) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 9 Nov 2026 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The candidate (M/F) will join the MMBCA team, led by Dr. Isabelle Schalk and Dr. Gaetan Mislin, within the BSC laboratory, a research unit (UMR 7242) affiliated with CNRS and the University of Strasbourg. Under the supervision of Dr. Olivier Cunrath, the candidate will work on an ambitious research project focused on studying intestinal bacteria and their ability to produce siderophores, key molecules involved in iron acquisition, an essential element for their survival and competition within the microbiome. This project aims to characterize siderophore production by these bacteria and assess their impact on the dynamics of the intestinal microbiota, by analyzing how these molecules influence the composition and balance of microbial communities and the resistance to pathogen colonization, by investigating whether siderophore production provides a competitive advantage to commensal bacteria, thereby limiting the establishment of pathogenic strains. This work adopts a multidisciplinary approach, combining methods from molecular microbiology, biochemistry, and genomic analysis to unravel the underlying mechanisms. This ANR-funded project offers the opportunity to contribute to a deeper understanding of microbial competition mechanisms in the gut, with potential implications for developing probiotic or therapeutic strategies targeting microbiota modulation.

Main Activities

Conduct bacterial culture experiments of intestinal strains (commensal and pathogenic) under controlled anaerobic conditions, particularly in iron-limited media, to study their siderophore production.
Investigate the impact of endogenous and exogenous siderophores on bacterial growth, survival, and competition within the intestinal microbiota.
Establish interaction models (co-cultures and cellular models) to analyze how siderophores influence intestinal colonization by commensal or pathogenic bacteria.
Analyze bacterial and cellular responses using techniques such as molecular biology (PCR, qPCR, sequencing), cell biology (flow cytometry, bacterial competition assays), microscopy (fluorescence) to visualize bacterial interactions.
Design and implement molecular biology strategies, including targeted mutagenesis to knock out or overexpress genes involved in siderophore synthesis or transport and the construction of reporter strains (e.g., fluorescent genes) to track in situ siderophore production.
Process and analyze experimental data (statistics, bioinformatics) to identify correlations between siderophore production, microbiota composition, and colonization resistance.
Present results clearly and rigorously (team meetings, reports, publications).
Actively contribute to the scientific interpretation and valorization of data (writing articles, conference presentations).
Work independently and collaboratively in a multidisciplinary environment (microbiology, biochemistry, chemistry).

Secondary Activities

Contribute to the general operation of the laboratory.
Manage inventory of reagents and consumables.
Order supplies and maintain equipment (e.g., anaerobic chambers, biosafety-level-appropriate equipment).
Participate in team meetings and scientific knowledge dissemination within the lab (seminars, training).
Conduct scientific literature reviews on advances related to siderophores, the intestinal microbiota, and microbial competition mechanisms.

The candidate (M/F) will work within the MMBCA team (Metals and Microorganisms: Biology, Chemistry, and Applications), led by Dr. Isabelle Schalk and Dr. Gaetan Mislin, at the BSC laboratory, a research unit (UMR 7242) under CNRS and the University of Strasbourg, located at the Research Institute of the École Supérieure de Biotechnologie de Strasbourg (ESBS). The team's biology website is: https://bsc.unistra.fr/en/research-teams/team-schalkmislin/presentation/ . The team consists of approximately 23 members, including biologists and chemists, fostering an interdisciplinary approach to scientific chall

M/F Research Scientist in Microbiology

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