PhD in Imaging and Molecular analysis of Takotsubo syndrome

il y a 1 semaine

Paris, France France Life Imaging Temps plein

Contexte et mission : OVERVIEW We are looking for a candidate for a science thesis in Cardiovascular Imaging and Pharmacology. Our laboratory is interested in the non‑destructive imaging analysis of energy metabolism and vascularization. We have recently introduced a new non‑invasive imaging technique to simultaneously study these two phenomena and their interactions with PETRUS, which, when applied to the exploration of cardiac pathologies, provides in‑depth information on mechanisms and pharmacological targets for treatment. PROJECT Takotsubo syndrome is a stress‑induced cardiomyopathy affecting mostly women. The clinical picture resembles an infarction without coronary artery obstruction; its prevalence is increasing and it exposes patients to fatal recurrences. There is no treatment. We have identified the metabolic pathways involved, making them potential therapeutic targets. LINES of RESEARCH The main axes of this research topic are: (1) to identify and/or confirm therapeutic targets by PETRUS imaging and molecular analysis, notably by Nanostring and mass spectroscopy; and (2) to experimentally treat Takotsubo syndrome with drugs against the identified targets in the case of (a) a single stress and (b) repeated stress. Work on small laboratory animals. Rémunération Application to the PhD scholarship for 3 years: Doctoral School ED 563, deadline May 5, 2022; see http://parcc.inserm.fr/research-teams/team/tavitian/ Compétences requises Willingness to pursue a career in medical research Good organizational skills Relational skills Rigor Autonomy The ability to adapt in an international multidisciplinary team, scientific curiosity and motivation are essential Contact Bertrand TAVITIAN. Phone: +33 1 53 98 80 54 - http://parcc.inserm.fr/research-teams/team/tavitian/ #J-18808-Ljbffr

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