Head Of Discovery

il y a 1 semaine


Paris, France BioTalent Temps plein

📢 We’re Hiring : Head of Discovery – Natural Products Chemistry & Bioactivity 📍 Paris, France 🕒 Full-time, Permanent 📅 Start : Flexible, 2026 Are you ready to lead ground breaking small-molecule discovery at the intersection of biology, chemistry, and computational innovation? We’re building a platform that uncovers the vast, untapped diversity of microbial natural products—unlocking new molecular scaffolds and novel modes of action to address major challenges in human health and agriculture. With a rapidly growing team and an industrial-scale discovery engine, we’re creating the next generation of bioactive molecules. 🎯 The Opportunity As Head of Discovery, you will lead small-molecule drug discovery programs from early hits through lead development. This is a senior scientific leadership role where you will shape strategy, guide multidisciplinary teams, and drive high-quality decision-making across bioassays, mechanism-of-action studies, target deconvolution, and lead refinement. You’ll work closely with leadership to prioritize programs, allocate resources, and maintain both speed and scientific rigor. Perfect for a hands-on discovery leader who thrives in fast-paced biotech environments and is excited by the unique power of microbial natural products. 🧪 What You’ll Lead Discovery Program Leadership Drive strategy and execution from hit confirmation to lead optimization Define milestones, go / no-go criteria, and ensure scientific robustness Integrate chemistry, biology, and platform insights into cohesive discovery paths Biology, Mechanism & Target Work Guide assay development and validation across microbiology, biochemical, and cell-based systems Oversee mode-of-action and target deconvolution efforts Translate multi-layer datasets into clear decisions and priority leads Candidate Refinement Partner with chemistry to support structure elucidation and SAR Steer potency, selectivity, and developability improvements (Bonus) Design or oversee in vivo proof-of-concept studies Team Leadership Manage and mentor a growing multi-disciplinary team Lead hiring for future discovery scientists Act as the key interface between discovery, platform, computational, and operations teams 👤 About You Must-have experience : Proven ability to advance small-molecule programs to the lead stage Expertise in bioassays, mechanism-of-action, target deconvolution , and candidate refinement Strong scientific leadership in biotech, pharma, or deeptech environments Excellent judgment, rigor, and data-driven decision-making Fluency in English Bonus : Background in natural products Experience with in vivo models Ability to collaborate across chemistry, biology, and computational disciplines If you're passionate about turning complex biology into actionable therapeutic leads—and helping shape a transformational discovery platform—this role offers rare impact and scientific breadth. Interested? Happy to share more—reach out #J-18808-Ljbffr


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