Advanced Pharmacometrics Expert
il y a 3 semaines
Passion for Innovation. Compassion for Patients.
Daiichi Sankyo Europe is dedicated to discovering, developing, and delivering new standards of care that enrich the quality of life around the world. With over 120 years of experience and more than 17,000 employees in over 20 countries, we strive to become a global pharma innovator with competitive advantage, creating novel therapies for people with cancer.
Main responsibilities:
- Collaborate with cross-functional colleagues to provide pharmacometrics solutions to support drug development
- Develop popPK models (especially for Antibody-drug conjugates ADCs) using preclinical and clinical data
- Develop PKPD semi-mechanistic models for tumor growth inhibition TGI and disease progression
- Develop dose and exposure-response models for different type of endpoints (continuous, binary, TTE, categorical, etc.)
- Implement clinical trial simulations for power calculation, optimization of study designs, and dose selection
- Create and manage small and large nonmem/monolix-like datasets for popPK and PK/PD analyses
- Respond quickly to urgent team requests
The ideal candidate should have a minimum of the following:
- A PhD, MD, or PharmD in Bioengineering or Pharmaceutical Sciences or Pharmacology, Statistics, Applied Mathematics, Engineering, or related field
- 1 to 3 years of industry/consulting experience or academic research working in R&D, pre-clinical and clinical environments
- Strong programming and dataset creation/management skills in R
- Experience with NONMEM and/or MONOLIX is a must. Experience with mrgsolve is a plus
- Good experience with popPK PK/PD analyses, dose-response and exposure response analyses
- Experience in model-based-meta analysis MBMA is a plus
- Good background in mathematics/statistics is a plus
- Experience with ADCs is a plus
Skills and Profile:
- Ability to work in a multi-cultural environment and willingness for collaborating, sharing and learning from others
- Passion for pharmacometrics analyses and ability to work independently and proactively
- Willingness to learning new methodologies and keeping track of the recent advances in fields related to pharmacometrics
- Good oral and written communication skills. Proficiency in spoken and written English and good knowledge of French
- Ability to work in a hybrid environment (mostly remote work but presence for one day each two weeks or each month is mandatory for f2f meetings and team building)
Why work with us?
Working at Daiichi Sankyo Europe is more than just a job – it is your chance to make a difference and change patients' lives for the better. We can only achieve this ambitious goal together. That is why we foster a culture of mutual respect and continuous learning, with a strong commitment to inclusion and diversity. Here, you will have the opportunity to grow, think boldly, and contribute your ideas. If you have a proactive mindset and passion for addressing the needs of patients, we eagerly await your application.
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