Postdoctoral Researcher

il y a 2 jours


Palaiseau, Île-de-France CNRS Temps plein

Job Offer: Postdoctoral Researcher (H/F): Image Analysis in Neurodevelopmental Biology

Reference: UMR7645-ANACHE-001

Number of Positions: 1

Work Location: PALAISEAU

Publication Date: mercredi 4 septembre 2024

Contract Type: CDD Scientifique

Contract Duration: 24 mois

Expected Start Date: 1 novembre 2024

Workload: Temps complet

Salary: 3081,33 à 4756,76 selon expérience

Required Education: Niveau 8 - (Doctorat)

Required Experience: Indifférent

Section(s) CN: Modélisation mathématique, informatique et physique pour les sciences du vivant

Job Description:

Missions:

The group "Microscopies avancées et physiologie des tissus" of the Laboratoire d'Optique et de Biosciences (LOB), École Polytechnique, Palaiseau, France, is seeking a postdoctoral researcher in image analysis for neurodevelopmental biology. The successful candidate will develop and optimize new strategies for automated 3D image analysis of large biological images. From a first operational pipeline, the goal is to extract more information, faster, and from more diverse data, to answer questions about brain tissue development.

Activities:

The postdoctoral researcher will work with experimental data obtained over two years at LOB, in close connection with the biological problems that motivated the production of these data. Two complementary subjects are initially considered: (i) polyvalent self-supervised learning for cell detection, segmentation, tracking, and classification in large images, and (ii) multi-scale registration between images recorded with different contrast modalities. Partial solutions have been implemented or described in the literature, particularly via statistical learning methods, which will be tested and adapted to multicolor data. According to the candidate, the project may take a more methodological or biological orientation.

Competences:

A PhD in computer vision, biomedical image analysis, or computational biology with a strong imaging component is required. Advanced programming skills in Python, statistical learning/IA, and image analysis are required. A marked interest and/or knowledge in microscopy and neuroscience would be an asset. The desire to work in an interdisciplinary team is, of course, necessary.

Work Context:

In the framework of a long-standing collaboration between the LOB's advanced microscopy group and the neurogenesis and circuit development group of the Institut de la Vision, we have developed an imaging technology allowing us to map with subcellular resolution 3D a whole mouse brain marked by a Brainbow multicolor approach revealing cellular lineages. We generate currently multicolumn data containing hundreds of billions of voxels, and significant efforts are currently underway to treat, analyze, and understand these data, particularly in collaboration with the computer science and AI department of the University of the Basque Country.

Constraints and Risks:

NA



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