Postdoctoral Researcher in Immunology

il y a 1 semaine


Paris, Île-de-France Imagine - Institut des maladies génétiques Temps plein
About us

The Imagine Institute is a cutting-edge research structure located within Necker Children's Hospital in Paris. Our research labs focus on understanding the molecular mechanisms of genetic diseases affecting the immune system, skeletal dysplasia, nervous system, stem cell differentiation, kidney physiology, and metabolism.

Mission

The Human Lymphohematopoiesis laboratory offers a postdoctoral position in immunology/molecular biology in the research group of Dr. Sven Kracker.

Research Project:

Activated PI3K delta syndromes (APDS type 1 and type 2) are combined immunodeficiencies with variable clinical manifestations. Clinical trials treating APDS type 1 and type 2 patients with p110 delta inhibitors indicate a great potential for this tailored therapeutic treatment.

In this project, we aim to identify novel markers for increased PI3K signaling to monitor treatment efficiency and characterize possible disease associations of genetic variants with uncertain significance in the APDS type 1 and type 2 associated genes, PIK3CD and PIK3R1, respectively.

Position Details:

We offer a challenging research project in a stimulating interdisciplinary environment.

  • Contract for 18 months (renewable), during which the successful candidate is expected to apply and secure an external fellowship.

  • Starting date: September/October.

  • Occasional remote work (mainly in the laboratory/office).

ProfileYour Profile:
  • Highly motivated scientist (PhD).

  • Experience < 6 months.

  • Creative and willing to take the initiative in the development and implementation of the project.

  • Strong interpersonal skills.

  • Solid background in immunology and cell biology.

  • Self-motivation and ability to work independently are vital.

  • Additional experiences in handling blood samples, flow cytometry, and RNA single-cell analysis are considered a plus, but excellent applicants eager to learn these techniques will be also considered.

Your Application:

Please send a motivation letter with a statement of research interest, a detailed CV with publication list, and two reference letters.



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