Postdoctoral Researcher in FGFR3-Related Disorders and Aging
il y a 6 jours
The Imagine Institute is a cutting-edge research structure located within Necker Children's Hospital in Paris. Our research labs focus on understanding the molecular mechanisms of genetic diseases affecting the immune system, skeletal dysplasia, nervous system, stem cell differentiation, kidney physiology, and metabolism.
We offer a unique environment where clinical and basic science synergize to produce groundbreaking contributions in areas like osteochondrodysplasia, immunology, molecular genetics, cell biology, and clinical research.
MissionWe are seeking a postdoctoral researcher to join our team in the laboratory of Molecular and Physiopathological Bases of Osteochondrodysplasia, led by Dr. Laurence Legeai-Mallet. The successful candidate will investigate the impact of FGFR3 signaling alterations on bone functions and premature aging.
The project aims to define the cellular and molecular regulatory pathways involved in these effects, decipher the complexity of multi-systemic impairments in FGFR3-associated disorders, and develop novel therapeutic approaches for adult FGFR3-related patients and premature bone aging.
The researcher will characterize the impact of FGFR3 mutation on skeleton, bone repair, and aging using mouse models of ubiquitous or bone-selective expression of this mutation. They will also investigate the therapeutic potential of FGFR3 antagonists in bone disorders and premature aging.
RequirementsWe are looking for a highly motivated postdoctoral researcher with a strong background in molecular and cell biology, and experience in mouse model research. The ideal candidate should have a PhD in a relevant field, be self-motivated, organized, and able to work independently. Fluency in English is required.
The position is offered for two years with a competitive salary depending on experience. Please submit a concise cover letter, detailed curriculum vitae, and contact information for two references with the candidate's permission.
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