Postdoctoral Researcher in FGFR3-Related Disorders and Aging

il y a 2 semaines


Paris, Île-de-France Imagine - Institut des maladies génétiques Temps plein
About Us

The Imagine Institute is a cutting-edge research structure located within Necker Children's Hospital in Paris. Our research labs focus on understanding the molecular mechanisms of genetic diseases affecting the immune system, skeletal dysplasia, nervous system, stem cell differentiation, kidney physiology, and metabolism.

We offer a unique environment where clinical and basic science synergize to produce groundbreaking contributions in areas like osteochondrodysplasia, immunology, molecular genetics, cell biology, and clinical research.

Mission

We are seeking a postdoctoral researcher to join our laboratory of Molecular and Physiopathological Bases of Osteochondrodysplasia, led by Dr. Laurence Legeai-Mallet. The successful candidate will investigate the impact of FGFR3 signaling alterations on bone functions and premature aging.

Our team studies rare skeletal disorders affecting bone and cartilage formation from early embryonic development to adulthood. We conduct pre-clinical studies to test and identify drugs that can correct long bone growth plate, craniofacial, and spine anomalies in FGFR3-related animal models.

Learn more about our team

Project

The project aims to define the cellular and molecular regulatory pathways involved in FGFR3-related disorders. We will decipher the complexity of multi-systemic impairments and develop novel therapeutic approaches for adult FGFR3-related patients and premature bone aging.

We will characterize the impact of FGFR3 mutation on skeleton, bone repair, and aging. The objective is to explore the functional impact of Fgfr3N534K/+ mutation on bone physiology, repair, and aging using mouse models of ubiquitous or bone-selective expression of this mutation.

We will investigate the therapeutic potential of FGFR3 antagonists in bone disorders and premature aging. Our preliminary data suggest that subcutaneous administration of FGFR3 antagonists modified the balance of bone formation and bone remodeling.

Profile

We are looking for a postdoctoral researcher with solid experience in molecular and cell biology, and in mouse model. The candidate must have a PhD in a relevant field and be self-motivated, organized, creative, and able to work independently and lead the project.

The position is offered for two years with a salary depending on experience. Please send a concise cover letter with a summary of previous and current research activity, detailed curriculum vitae, and the contact information for two references.



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