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Postdoctoral Researcher in Complement System Biology

Il y a 2 mois


Grenoble, Auvergne-Rhône-Alpes, France CEA Temps plein
Description de l'offre

Our research team at the CEA is dedicated to advancing the understanding of the complement system and its structural components. We are seeking a highly motivated and talented postdoctoral researcher to contribute to our cutting-edge project on the antigenic determinants and pathogenicity of anti-C1q autoantibodies in systemic lupus erythematosus.

Key Responsibilities
  • Recombinant Expression and Purification of C1q and its fragments: Utilize advanced recombinant techniques to produce and purify complement C1q and its variants.
  • ELISA Analysis: Conduct precise identification of the domains of C1q targeted by autoantibodies in sera from SLE patients and control groups.
  • Autoantibody Characterization: Conduct in-depth analysis of purified autoantibodies from SLE patient plasma to understand their interactions and implications in the disease pathophysiology.
  • Structural Exploration: Employ complementary structural approaches to explore how C1q conformation modulates epitope access and gain comprehensive insights into the behavior and function of C1q and their perturbation by autoantibody interactions.
Requirements
  • Ph.D. in Biochemistry, Molecular Biology, or a related field.
  • Strong experience in recombinant protein expression and purification.
  • Proficiency in ELISA and other immunoassays.
  • Familiarity with structural biology techniques will be greatly appreciated.
  • Passion for scientific discovery and a collaborative spirit.
Accommodations and Inclusion

In accordance with the commitments made by the CEA in favor of the integration of people with disabilities, this job is open to everyone. The CEA offers accommodations and/or organizational possibilities for the inclusion of disabled workers.