Senior Research Scientist
il y a 4 semaines
Pharmiweb is seeking a highly qualified Research Scientist to join their team in accelerating medication discovery for difficult disease targets. The successful candidate will play a crucial role in creating novel pharmaceutical compounds and advancing their understanding of interactions with biological systems.
Key Responsibilities:
- Model and simulate how possible medication candidates interact with biological targets using computational approaches.
- Create and configure simulations using molecular dynamics according to the goals of the study.
- Examine and evaluate how drug candidates bind to target proteins, considering thermodynamics and binding affinities.
- Conduct experiments and computational simulations to understand the physicochemical properties of drug molecules and their impact on pharmacokinetics and pharmacodynamics.
- Use computational methods and protein structures to inform the logical design of novel medicinal drugs.
- Prepare tiny compounds by chemical synthesis, purification, and characterisation for simulations or studies.
- Work together with diverse groups of scientists, biologists, medicinal chemists, and other experts to incorporate computational results into drug discovery initiatives.
- Assist in the writing of reports, research papers, and patents pertaining to the development and discovery of new drugs.
Requirements:
- PhD in physical chemistry, biophysics, theoretical chemistry, or a similar discipline with an emphasis on molecular modelling and drug design.
- Proficient knowledge of protein-ligand interactions, computational chemistry, and molecular modelling.
- Multiple years' experience in a Biotechnology/Pharmaceutical/CRO environment.
- Experience with atomistic and AMOEBA force fields, and their application in molecular simulations and drug discovery.
- Expertise in utilising tools and software for drug discovery, such as structure-based drug design platforms, docking software, and molecular dynamics simulations.
- Proficiency in RNA mechanism and interactions, as well as RNA structural dynamics and RBP.
- Strong problem-solving and analytical skills, especially in the context of drug design.
- Excellent written and oral communication skills, with the ability to communicate complex scientific concepts to diverse audiences.
- Demonstrated record of research publications and contributions to drug discovery.
- Ability to work independently and collaboratively within a team.
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