Translation Regulation and Hematopoise

il y a 4 jours

Grenoble, France GIN Grenoble Institut des Neurosciences Temps plein

**Translation regulation and hematopoise**:

- Réf **ABG-132358**
- Sujet de Thèse
- 04/06/2025
- Financement public/privé
- GIN Grenoble Institut des Neurosciences
- Lieu de travail- Grenoble - Auvergne-Rhône-Alpes - France
- Intitulé du sujet- Translation regulation and hematopoise
- Champs scientifiques- Biologie
- Biochimie
- Mots clés- megakaryopoiesis, translation regulation, ribosome, human disorders

**Description du sujet**:
RNAseq. Additional knowledge in mouse handling and microscopy is a plus. We offer a close supervision in both motivated teams and a stimulating scientific environment for a transdisciplinary project. The postdoc will
have access to state-of-the-art equipment related to the project. She/he will interact with interdisciplinary groups and will receive mentoring for career development.

**Nature du financement**:

- Financement public/privé

**Précisions sur le financement**:

- ANR

**Présentation établissement et labo d'accueil**:

- GIN Grenoble Institut des Neurosciences

The laboratory is part of the GIN Grenoble Institute of Neurosciences, at Inserm and Grenoble Alpes University research center devoted to understanding brain functions in health and diseases. The GIN is composed of research teams specialized in the study of physiological processes or in pathologies of the nervous system and in the development of innovating techniques to explore them and provides with the state-of-the-art platforms and technologies. The GIN is founder member of the Grenoble center of excellence in neurodegenerative disorders (GREEN). Grenoble is an active research city in France located three hours from Paris by train.

**Site web**:
Background: Over the past decade, genetic lesions that cause ribosome dysfunctions have been identified in
both congenital and acquired human disorders. These ribosome modifications can directly impact translation
levels and quality in cells. Very recent data underline that ribosome biogenesis is involved in mediating the
transition between proliferation and differentiation of erythroid progenitors. The functional consequences of
translation and protein synthesis regulation on megakaryopoiesis remains largely unexplored. Our preliminary
data suggest that translation regulation and modification of the ribosomal protein RPS6 might have a critical
role in the megakaryopoiesis and platelet formation.
The goal of the postdoctoral project is to determine the role of the translation regulation during
megakaryopoiesis and to explore the potential roles of the ribosomal protein RPS6 in this process.
Qualification: We seek an enthusiastic, highly motivated post-doctoral fellow to work on translation regulation
molecular biology and biochemistry with knowledge in cell culture, western blot, immune-fluorescence and
RNAseq. Additional knowledge in mouse handling and microscopy is a plus. We offer a close supervision in
both motivated teams and a stimulating scientific environment for a transdisciplinary project. The postdoc will
have access to state-of-the-art equipment related to the project. She/he will interact with interdisciplinary groups
and will receive mentoring for career development.

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