Multiscale Structuring and Assembly of Chitosan Films for Eco-friendly Lab-on-a-chip Applications

il y a 1 semaine

Villeurbanne, France INL (Institut des Nanotechnologies de Lyon) (Doua) Temps plein

Réf **ABG-131722**
- Sujet de Thèse
- 06/05/2025
- Contrat doctoral
- INL (Institut des Nanotechnologies de Lyon) (Doua)
- Lieu de travail- Villeurbanne et Ecully - Auvergne-Rhône-Alpes - France
- Intitulé du sujet- Champs scientifiques- Sciences de l’ingénieur
- Biotechnologie
- Ecologie, environnement
- Mots clés- Chitosan; micro
- and nano-fabrication, Lab-on-a-chip; Microfluidics; Surface functionalization

**Description du sujet**:
Context

Objective of the thesis

We have recently developed at INL, in collaboration with IMP (Institut des Matériaux Polymères), a process to obtain thick films of chitosan and demonstrated that it is possible to micro-structure them to make LOCs [3]. Chitosan, a polysaccharide derived from chitin and the second most abondant after cellulose on Earth, is produced from waste generated by the seafood industry (6 to 8 million tonnes per year [4]). Although we have succeeded in making the first LOCs from chitosan, there are still some technological hurdles to overcome. The aim of this thesis is therefore to pursue research into the manufacture of LOC made from chitosan, in order to propose a fully eco-responsible manufacturing process. The objectives of this thesis are:

- Optimize the chitosan film manufacturing process to obtain films that are insoluble in aqueous media or with a swelling rate of less than 10%.
- Study multi-scale (micro and nano) structuring of chitosan films by micro-drilling, nano-imprinting, hot-embossing and plasma etching.
- Design and manufacture LOC devices with different functions (separation, sorting, concentration, capture, detection).
- Evaluate fabricated LOCs with model systems such as beads for sorting or separation functions, or the streptavidin-biotin couple for capture and detection functions.

**Prise de fonction**:

- 01/10/2025

**Nature du financement**:

- Contrat doctoral

**Précisions sur le financement**:
**Présentation établissement et labo d'accueil**:

- INL (Institut des Nanotechnologies de Lyon) (Doua)

**Site web**:
- 19/05/2025

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