Postdoctoral Position
il y a 4 jours
**About us**:
Premier pôle européen de recherche, de soins et d’enseignement sur les maladies génétiques créé en 2007 au cœur du campus de l’Hôpital Necker-Enfants malades. Sa mission ? Mieux comprendre les maladies génétiques pour mieux les guérir.
L’Institut Imagine est un endroit unique au monde qui rassemble chercheurs, patients, médecins et personnels de santé dans une architecture créatrice de synergies au service d’une même ambition : changer la vie des familles touchées par les maladies génétiques.
**Mission**:
**Background and rationale**:
In the field of cutting-edge research and academic excellence, the NEPHRO-GAP project aims to develop an allele specific ASO-based therapy for monogenic kidney disease including steroid-resistant nephrotic syndrome, a hereditary kidney disease that systematically progresses to end-stage renal failure. The identification of its genetic causes, the study of its pathophysiology and the development of new therapeutic solutions have been and continue to be the focus of intense research in the Hereditary Kidney Disease Laboratory at the Imagine Institute in Paris.
**Objectives**:
The aim of this funded (ANR) project is to test already identified gapmers ASOs for allele specific degradation of a monogenic kidney disease. The project will be carried out in the Hereditary Kidney Diseases Laboratory and will use different models such as kidney organoids and mice model to identify and test different ASOs. Cutting edge technologies (Targeted RNA sequencing, Single cell RNA sequencing) and confocal imaging will be pivotal analyses of this project. Our lab already developed ASO based therapy for monogenic kidney diseases using kidney organoids.
**Profile**:
**Expected skills**:
This project involves cell and organoid culture and therefore requires skills in cell culture as well as molecular biology and protein studies. In addition, the RNAseq aspect of this project involves bio-computing analyses, and skills in handling this tool are highly desirable.
**Localization**:
**Duration**:
36 months
**Application**:
-
Postdoctoral Researcher
il y a 2 jours
Paris, France INSERM Temps pleinOverview Join to apply for the Postdoctoral Researcher role at INSERM. We are hiring for a two-year postdoc in whole brain modelling of Amyotrophic Lateral Sclerosis, starting in May 2026 at the Biomedical Imaging Laboratory (LIB) in Paris, France. Responsibilities Fit existing TVB models to multimodal data from ALS patients and controls. Use the models for...
-
Postdoctoral Position On Fgfr3-related Disorders
il y a 4 jours
Paris, France Institut Imagine Temps plein**About us**: The _Imagine_ Institute (IHU, ‘Institut Hospitalo-Universitaire’, INSERM U1163) is a recent research structure located within Necker Children’s Hospital (Paris). Its research labs are focused on understanding the molecular mechanisms of genetic diseases that affect the adaptive and innate immune systems, the skeletal dysplasia, the...
-
Postdoctoral Position in Asymmetric Heart Morphogenesis
il y a 4 jours
Paris, France Institut Imagine Temps plein**About us**: The _Imagine_ Institute (IHU, ‘Institut Hospitalo-Universitaire’, INSERM U1163) is a recent research structure located within Necker Children’s Hospital (Paris). Its research labs are focused on understanding the molecular mechanisms of genetic diseases that affect the adaptive and innate immune systems, the skeletal dysplasia, the...
-
Postdoctoral Position
il y a 4 jours
Paris, France Institut Imagine Temps plein**About us**: The _Imagine_ Institute (IHU, ‘Institut Hospitalo-Universitaire’, INSERM U1163) is a recent research structure located within Necker Children’s Hospital (Paris). Its research labs are focused on understanding the molecular mechanisms of genetic diseases that affect the adaptive and innate immune systems, the skeletal dysplasia, the...
-
Postdoctoral Position in Immunology
il y a 4 jours
Paris, France Institut Imagine Temps plein**About us**: The _Imagine_ Institute (IHU, ‘Institut Hospitalo-Universitaire’, INSERM U1163) is a recent research structure located within Necker Children’s Hospital (Paris). Its research labs are focused on understanding the molecular mechanisms of genetic diseases that affect the adaptive and innate immune systems, the skeletal dysplasia, the...
-
Open call for a junior research group leader position
il y a 4 jours
Paris, France Institut de la Vision Temps pleinThe Institut de la Vision is seeking candidates for a Junior Group Leader position with a focus on molecular and cell biology to the field of retinal development and regeneration.The successful candidate will create her/his own team for developing and implementing innovative approaches to address key challenges in understanding of retinal development and...
-
Postdoctoral Position in Adhesion Along
il y a 1 semaine
Paris, France Laboratoire Navier Temps plein**Site web**: **Poste et missions**: Significant efforts have been made in the past decades to unravel the influence of material heterogeneities on the failure behavior of composites. The apparent fracture properties of brittle composites are strongly controlled by the various local failure mechanisms involved at the crack tip during the interaction of the...
-
ALS Brain Modelling Postdoc
il y a 2 jours
Paris, France INSERM Temps pleinA research institution is seeking a Postdoctoral Researcher in Paris for a two-year project on whole brain modelling of Amyotrophic Lateral Sclerosis. The candidate will fit TVB models to multimodal data, collaborate with clinicians, and maintain autonomy in research. Candidates should have expertise in neuroimaging and a background in computational...
-
Paris, France France Life Imaging Temps pleinOverviewType de structure : A postdoctoral position in radiomics of liver diseases is currently available at the Laboratory of Imaging Biomarkers of the Center of Research on Inflammation UMR 1149 INSERM - University Paris Diderot. The Center for Research on Inflammation Research, Inserm unit UMR1149, was created in 2014 and is distributed on the Bichat and...
-
Postdoctoral Researcher
il y a 4 jours
Paris, Île-de-France INSERM Temps pleinInserm is the only French public organisation entirely dedicated to biological, medical and population health research. It has research laboratories throughout France, grouped into 12 Regional Delegations. Our institute brings together 15,000 researchers, engineers, technicians and administrative staff with a common goal: to improve everyone's health through...
