Development of Biomimetic Tools for Cartilage
il y a 1 semaine
**Development of biomimetic tools for cartilage tissue engineering**:
- Réf **ABG-126212**
- Stage master 2 / Ingénieur- Durée 6 mois- Salaire net mensuel 659,76 €- 10/10/2024- Centre national de la recherche scientifique- Lieu de travail- Lyon Auvergne-Rhône-Alpes France- Champs scientifiques- Biologie
**Établissement recruteur**:
**Site web**:
The internship offer is to join our “Regeneration of OsteoArticular and Dental tissues” (ROAD) team within the LBTI (Laboratory for Tissue Biology and Therapeutic Engineering). Our laboratory is part of the IBCP research institute and located on the Gerland campus, providing an excellent research environment, core facilities and support services. This internship will be supervized by Jean-Daniel Malcor, whose research focuses on modelling collagen and designing biomaterials for tissue engineering.
**Description**:
- Objectives-
- Approach- Biomaterials will be produced as hydrogels (from PEG or alginate) functionalized with ligands for collagen-binding receptors, in particular α10β1, which have recently been discovered in our laboratory. These ligands are triple-helical peptides (THPs), a family of peptides that adopt the characteristic triple helix structure of collagen. In this 3D culture system, CSMs encapsulated in hydrogels will be differentiated in chondrocytes in the presence of growth factors et mechanical stimulation. CSM/biomaterial interactions will be provided by THP recognition by collagen-binding receptors, thus mimicking natural interactions between cells and the ECM. CSM differentiation will be monitored by immunofluorescence and PCR, probing for transcription factors or markers for chondrocytes (_SOX9_, _ACAN_, _COL2_ et _COL9_) or other lineages (for instance _Osx_, _Runx2_, _COL1_, _COL10_ for osteocytes or hypertrophic chondrocytes). We will also explore α10β1 integrin activation and associated signalling pathways (MAP kinase phosphorylation, actin polymerisation, formation of focal adhesion points). Finally, we will study the ability of differentiated CSMs to produce ECM corresponding to that of cartilage, by analysing both its composition (by immunofluorescence, western blot and mass spectrometry) and its bio-mechanical properties (by measuring rigidity and elasticity of engineered cartilage tissues obtained in the presence of mechanical constraints similar to those found in joints of the hip or the knee).**Profil**:
**Prise de fonction**:
- 01/01/2025
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