Master-level Internship

**Master-level internship (Master 2) in Innovative Therapeutics and Precision Oncology**: - Réf **ABG-133314** - Stage master 2 / Ingénieur - Durée 6 mois - Salaire net mensuel Gratification selon la réglementation en vigu - 04/09/2025 - UMR Inserm U1086 Anticipe - Lieu de travail- Caen Normandie France - Champs scientifiques- Santé, médecine humaine, vétérinaire - Biologie - Biotechnologie **Établissement recruteur**: **Site web**: **Host**Laborato**ry** Laboratory : The Anticipe Unit conducts both fundamental and applied research to offer cancer prevention or treatment strategies best adapted to individuals and their environment. In daily interaction with clinicians from the University Hospital and François Baclesse Comprehensive Cancer Center, the unit comprises about a hundred people and two main research axes: "Cancers and Prevention" and "Precision Medicine for Ovarian Cancer." This project is part of the "**Precision Medicine for Ovarian Cancer**" axis and is a new theme within the unit, involving the **THERANOVCA Excellence Chair in innovative**theranostic** approaches for ovarian cancers and the international partner laboratory RECITAL with the University of Sherbrooke (QC, Canada)**. Supervision : Dr. Élie Besserer-Offroy, Assoc. Prof. et Dr. Cécile Pétigny, Assoc. Researcher. Expertise : Pharmacology of G protein-coupled receptors (GPCRs), Nuclear Medicine and Theranostics, Radioligand Development, Ovarian Cancer, Precision Medicine. **Description**: **General**Information**Duration : 5 to 6 months- Dates : January 2026 - July 2026 (_dates flexible according to academic calendar_)- Level : Enrollment in a Master-level program- Gratification : According to current French regulations- Localisation : Interdisciplinary Research Unit for Cancer Prevention and Treatment, Caen, France [Inserm U1086 - ANTICIPE, Université de Caen-Normandie]**Internship Context** Locally aggressive cancers, especially ovarian cancers, represent major therapeutic challenges requiring the development of new diagnostic and therapeutic strategies. In this context, innovative preclinical models are essential for evaluating the efficacy of new therapeutic molecules. This internship is part of a research project aimed at developing new theranostic molecules, combining molecular imaging and radioligand therapies (targeted radionuclide therapy). The work carried out during this internship will provide the methodological foundations for a future doctoral project. **Internship**Objecti**ves** - Main _Objecti_ve_ To develop and optimize innovative tumor models on the chicken chorioallantoic membrane (CAM) for the study of therapeutic targets and the evaluation of new therapeutic strategies in locally aggressive cancers, particularly ovarian cancers. - Specific _Objecti_ves_**Development of in**ovo** CAM models**:Establish standardized protocols for the implantation and follow-up of ovarian tumors on the CAM during embryonic development.- **Optimization of ex**ovo** CAM models**:Develop ex ovo culture methods allowing better access and longitudinal monitoring of tumors.- **Characterization of models**:Validate tumor growth, vascularization, and expression of relevant therapeutic targets. **Standardization of protocols**:Establish reproducible procedures for future use in the doctoral project.**Profil**: **Desired**Profil**e** - R_equi_red_ _Skills_Background in biology, biotechnology, pharmacology, or related fields - Basic knowledge in cancer biology - Strong organizational skills and scientific rigor - Autonomy and initiative - Good writing skills - Basic pharmacology knowledge - Good proficiency in scientific English - Additional_ _Valued_ _Skills_Experience with cell culture - Basic molecular biology techniques - Knowledge in biomedical imaging - Experience in histology techniques **Perspectives** This internship offers an excellent opportunity to: - Gain expertise in innovative preclinical models - Participate in the development of new therapeutic approaches - **Prise de fonction**: - Dès que possible