Grammar and Neuronal Representations of Social Behavior in Murine Model of Neurodevelopmental Psychiatric Diseases

**Grammar and Neuronal Representations of Social Behavior in Murine Model of Neurodevelopmental Psychiatric Diseases**:

- Réf **ABG-129164**
- Sujet de Thèse
- 05/03/2025
- Contrat doctoral
- NeuroSchool, Aix-Marseille Université
- Lieu de travail- Marseille - Provence-Alpes-Côte d'Azur - France
- Intitulé du sujet- Grammar and Neuronal Representations of Social Behavior in Murine Model of Neurodevelopmental Psychiatric Diseases
- Champs scientifiques- Psychologie, neurosciences
- Biologie
- Santé, médecine humaine, vétérinaire
- Mots clés- neuroscience, neurobiology, cognition, neural networks, brain, behavior, neurodegenerative diseases, ageing,

**Description du sujet**:
**_The NeuroSchool PhD Program of Aix-Marseille University (France) has launched its annual calls for PhD contracts for students with a master's degree in a non-French university and for international co-supervised PhDs._**

**_This project is one of the proposed projects. Not all proposed projects will be funded, check our website for details._**

1. Characterizing the fundamental elements of behavioral dynamics in groups of mice using deep learning and advanced statistical tools to uncover the structure of social behavior.

2. Identifying neural representations associated with specific behavioral modules by measuring neuronal ensembles activity in prefrontal hubs.

3. Establishing a quantitative framework to analyze behavioral grammar and its neural representations in a genetic model of neurodevelopmental psychiatric disease.

**Expected results**:Expected results: By integrating multidisciplinary approaches and cutting-edge technologies, this study will 1- quantify alterations in multidimensional data from freely interacting social groups to predict the consequences of these disturbances, and 2- advance understanding of how neuropsychiatric disorders affect social behaviors and 3- identify new potential therapeutic targets.

**Methods**:Natural social interactions in group-housed mice will be continuously tracked and monitored in real time using the Live Mouse Tracker, a system integrating computer vision and machine learning8-9. Structured neuronal ensemble activity will be recorded in awake, freely moving, and socially interacting mice using fiber photometry. Multimodal data and social behavioral grammar will be analyzed and decoded through advanced statistical and algorithmic approaches, Bayesian modeling and Markovian Processes.

**Prise de fonction**:

- 01/10/2025

**Nature du financement**:

- Contrat doctoral

**Précisions sur le financement**:

- 3 years

**Présentation établissement et labo d'accueil**:

- NeuroSchool, Aix-Marseille Université

Within **Aix Marseille Université, NeuroMarseille**brings together 8 research laboratories and NeuroSchool, a graduate school in neuroscience, to increase the attractiveness of the university, international collaborations, interdisciplinarity, links with the clinical and industrial worlds and the integration of students into professional life.

Launched in July 2018, **NeuroSchool**unifies and harmonizes the training of the third year of the Bachelor of Life Sciences (Neuroscience track), the Master's and the PhD in Neuroscience.

**Site web**:
**Intitulé du doctorat**:

- Doctorat de neurosciences

**Pays d'obtention du doctorat**:

- France

**Etablissement délivrant le doctorat**:

- Aix Marseille Université

**Ecole doctorale**:

- Sciences de la vie et de la santé
- Master's degree from a non-French university in neuroscience or related field
- Fluent in English
- Strong attraction for computation and statistics - Collaborative and positive team spirit.- 14/04/2025