Scientist / Junior Scientist in Biomolecular NMR Spectroscopy (M/F)

Job Description

Under the supervision of the Head of NMR, you will join a multidisciplinary Structural Biology and Biophysics team supporting pharmaceutical and biotechnology clients in their drug discovery programs.

Working closely with experts in Surface Plasmon Resonance (SPR), Native Mass Spectrometry, HDX-MS, Cryo-EM and X-ray Crystallography, you will contribute to the characterization of biomolecular interactions and the structural investigation of proteins and protein-ligand complexes.

You will be expected to:

• Design, perform and interpret advanced biomolecular NMR experiments for protein and protein-ligand characterization.
• Conduct ligand-observed and protein-observed NMR assays to support hit identification, hit validation and fragment-based drug discovery projects.
• Perform multidimensional NMR analyses to characterize binding events, chemical shift perturbations and structural changes induced by ligand binding.
• Independently perform resonance assignments using state-of-the-art methodologies and computational tools.
• Analyze and interpret NMR datasets to provide structural and mechanistic insights supporting client projects.
• Contribute to the development, validation and implementation of new NMR methodologies and applications.
• Prepare protocols, SOPs and technical documentation.
• Present results to internal teams and clients through written and oral reports.
• Participate in troubleshooting activities and continuous improvement of NMR workflows and instrumentation.

Profile

We are looking for a dynamic, motivated and scientifically curious NMR scientist to join the Structural Biology and Biophysics team.

Major Requirements

• PhD in Structural Biology, NMR Spectroscopy, Biophysics
• Strong theoretical and practical expertise in biomolecular NMR spectroscopy.
• Hands-on experience operating high-field NMR spectrometers (600, 700 and/or 800 MHz).
• Proven experience in the characterization of protein-ligand interactions using ligand-observed and/or protein-observed NMR approaches.
• Experience with multidimensional NMR experiments and resonance assignment strategies.
• Ability to independently analyze complex datasets and derive biologically relevant conclusions.
• Excellent written and verbal communication skills in English.
• Strong organizational skills and ability to manage multiple projects simultaneously.
• Ability to work efficiently in a multidisciplinary and client-oriented environment.

Additional Assets

• Experience in fragment-based drug discovery (FBDD).
• Knowledge of complementary biophysical techniques such as SPR, MST, ITC, DLS or Native MS.
• Experience in method development and automation of NMR workflows.

Personal Skills

• Strong analytical and problem-solving abilities.
• Scientific rigor and experimental autonomy.
• Ability to translate complex structural information into actionable project recommendations.
• Excellent communication and presentation skills.
• Collaborative mindset and team spirit.
• Curious, innovative and proactive attitude.i>
• Strong client-service orientation.

Languages

• Fluent English, written and spoken.

Start of contract: as soon as possible.

Type of contract: permanent position.