Biomechanics of Desmin-related Cardiomyopathy
il y a 5 jours
**Biomechanics of desmin-related cardiomyopathy**:
- Réf **ABG-122241**
- Sujet de Thèse- 04/04/2024- Contrat doctoral- Institut of Light Matter, Biophysics Team- Lieu de travail- Villeurbanne - Auvergne-Rhône-Alpes - France- Intitulé du sujet- Biomechanics of desmin-related cardiomyopathy- Champs scientifiques- Physique
- Biologie
- Informatique
- Mots clés- Biophysics, 3D imaging, 3D models, traction forces, in-silico modeling**Description du sujet**:
**Context**:
**Thesis description**:
- The goal of the thesis will be two sides: first to extent the development of new software tools for the automatic robust and fast analysis of in vitro assays, which is crucial for the drug screening aspect of the project and second to build an integrative model of the disease based on all the different data types gathered by the partners of the project and especially to try to link structural defaults (sarcomere, desmosomes organization), to their consequences in force transmission, and in particular to study the coupling with rhythms disorders.- The thesis will be performed in strong collaboration with the **Stem Cell and biotherapy Team (IBPS, Paris)**
- Dr. Pierre Joanne, Dr. Onnik Agbulut.**Prise de fonction**:
- 02/09/2024**Nature du financement**:
- Contrat doctoral**Précisions sur le financement**:
- IPV**Présentation établissement et labo d'accueil**:
- Institut of Light Matter, Biophysics TeamThe Biophysics team research topics are centered on the study of cell movements, in particular the emergence of collective behaviors, on the coupling between mechanics and biology for stem cells or tissues (mechano-genetic regulation, tissue rheological properties), and finally on the development of culture and analysis platforms (organ-on-chip) as well as opto-acoustic methods for the characterization of 3D cellular models. These 3D models are multicellular spheroids of cancerous, embryonic or stem cells.
We are developing original methods for measuring forces, mechanical properties and observing the movement and change of shape of cells using homemade routines.
Our projects are carried out in collaboration with cancer biologists (we are affiliated with the François Rabelais Institute for multidisciplinary cancer research) and developmental biologists (Hydra, Dictyostelium, plants, protists), engineers of microsystems, polymer chemists, theorists of statistical physics or applied mathematics.
**Site web**:
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**Areas of expertise** : Interest in experimentation and modeling. Good programming skills in any language is required and a background in biology would be highly appreciated.**Personal qualities**: teamwork, autonomy and organizational skills, adaptability, curiosity.-
- 30/06/2024
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