Postdoctoral Position in Advanced Crystallography
Il y a 2 mois
**General information**:
**Organisation **:The French Alternative Energies and Atomic Energy Commission (CEA) is a key player in research, development and innovation in four main areas:
- defence and security,
- nuclear energy (fission and fusion),
- technological research for industry,
- fundamental research in the physical sciences and life sciences.
Drawing on its widely acknowledged expertise, and thanks to its 16000 technicians, engineers, researchers and staff, the CEA actively participates in collaborative projects with a large number of academic and industrial partners.
The CEA is established in ten centers spread throughout France
**Reference **:2023-29986
**Division description**:
**Description de l'unité**:
The IBS is an internationally recognized research center in the field of integrated structural biology. Our institute explores the structure and dynamics of proteins and other biological macromolecules to understand how they function at the atomic level and in a cellular environment.
Biological phenomena - such as host cell defenses against infection, membrane transport, molecular mechanisms of cancer, adaptation of molecules to extreme environments, DNA repair, epigenetic regulation and programmed cell death - are highly complex. To understand these and other fundamental cellular processes, we aim to obtain an accurate description of the biological molecules involved by studying their structure, dynamics and interactions with molecular partners and by elucidating the relationship between their structure and function.
Current challenges in structural biology include the structure determination of large macromolecular assemblies and the understanding of protein dynamics within such assemblies or in a cellular environment. Such challenges require a multidisciplinary approach at the interface of biology, physics and chemistry, as well as powerful instruments and methods of analysis spanning different resolution scales, available at the institute or nearby. Establishing multidisciplinary collaborative networks is also critical for the success of our research.
**Position description**:
**Category**:
Biology, biophysics and biochemistry
**Contract**:
Fixed-term contract
**Job title**:
Postdoctoral position in advanced crystallography to study radical SAM enzymes H/F
**Socio-professional category**:
Executive
**Contract duration (months)**:
24
**Job description**:
The Metalloproteins Unit of the Institut de Biologie Structurale, that joins the collaborative research efforts between the University Grenoble Alps (UGA), the French National Centre for Scientific Research (CNRS), and the French Alternative Energies and Atomic Energy Commission (CEA) in Grenoble, France, is actively seeking a postdoctoral researcher. This position aims at the structural characterization of reactive intermediates in the time course of radical SAM enzymes, involved in the assembly of the [FeFe]-hydrogenase active site. The research will be primarily performed at IBS in close collaborations with the SyMMES/CAMPE group led by Serge Gambarelli and the European Synchrotron Radiation Facility ID29 beamline led by Daniele de Sanctis. These three laboratories are located within the same scientific campus in Grenoble, France, and have a longstanding tradition of collaborations in their respective fields of study.
The postdoctoral researcher will be responsible for the production of protein samples using already established reproducible protocols in the laboratory, to prepare microcrystals for structural studies through serial crystallography. They will also oversee the development of a sample holder for anaerobic work to prevent damage caused by oxygen to both metal cofactors and radical intermediates. Finally, they will be in charge of coupling photosensitizers to the protein to synchronize the radical reaction in crystals, enabling the measurement of diffraction data at different time points and capturing the sought-after intermediates.
**Applicant Profile**:
**Qualifications**
We seek a motivated and open-minded researcher with strong communication skills, who thrives in a collaborative, multidisciplinary team. Prior knowledge of the French research system would be a valuable asset for increased autonomy in the role.
**Position Summary**
Funding for this position has been awarded by the French National Research Agency (ANR) as a part of a broader French project. The position can start anytime between March 2024 and October 2024. The initial contract will run for 24 months with a possible 1-year extension.
**Applications**
**In accordance with the commitments made by the CEA in favor of the integration of people with disabilities, this job is open to all.**
**Position location**:
**Site**:
Grenoble
**Job location**:
France, Auvergne-Rhône-Alpes, Isère (38)
**Location**:
Grenoble
**Languages**:
English (Bilingual)
**Requester**:
**Position start date**:
01/03/2024
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Grenoble, France CEA Temps pleinDescription du poste Domaine Biologie, biophysique et biochimie Contrat Post-doctorat Intitulé de l'offre Postdoctoral position in structural biology to study radical SAM enzyme mechanisms H/F Durée du contrat (en mois) 25
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Grenoble, France CEA Temps pleinDescription du poste Domaine Biologie, biophysique et biochimie Contrat Post-doctorat Intitulé de l'offre Postdoctoral position in structural biology to study radical SAM enzyme mechanisms H/F Durée du contrat (en mois) 25
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