Senior Laboratory Technician/Engineer

Senior Laboratory Technician/Engineer – Early CMC / Lead Identification We are an innovative biotech company specializing in the development of next-generation therapeutics (single-domain antibodies, conjugates, siRNA, etc.). Our agile and passionate R&D team works on cutting‑edge projects in immunology, oncology, and rare diseases. Job Summary We are seeking a highly motivated Senior Laboratory Technician to join our Early CMC / Lead Identification team. The ideal candidate is an experienced cell biologist with hands‑on expertise in cellular binding assays (FACS), internalization identification, RNA extraction, RT-qPCR, and cell culture. This role is central to the early qualification of therapeutic candidates and requires strong experimental rigor, autonomy, and the ability to work collaboratively in a dynamic biotech environment. The role reports directly to the Director, Early CMC. Keys Responsibilities Cell-based Assays & Lead Characterization Perform cellular binding assays by flow cytometry (FACS) to characterize candidate molecules. Design and execute internalization assays (microscopy, FACS-based internalization, etc.). Prepare and maintain cell lines needed for screening and characterization. Perform RNA extraction, reverse transcription, and RT-qPCR for gene expression profiling and target quantification. Perform protein extraction and Western Blots for protein levels quantification. Quantitatively analyze internalization or signaling markers from cell-based experiments. Culture, expand, and bank a variety of cell lines (adherent and suspension). Validate cellular models for target expression (flow cytometry, RT-qPCR). Data Collection, Analysis & Reporting Ensure rigorous data recording following internal quality standards (ELN, SOPs). Analyze and interpret experimental results; present data to project teams. Contribute to troubleshooting and optimization of experimental workflows. Cross-functional Collaboration Work closely with Antibody Discovery, Chemistry, and CMC teams to support pipeline progression. Participate in the development of early CMC packages (binding, internalization, expression analysis). Qualifications & Experience required Bachelor or Master’s degree (BTS, DUT, Licence, Master, or equivalent) in Cell Biology, Molecular Biology, Biotechnology, or a related field. ≥7‑10 years of laboratory experience in biotech, pharma, or academic research (industry experience preferred). Familiarity with early CMC workflows and lead evaluation is a plus. Hands‑on experience with flow cytometry (FACS) for cellular binding assays is required. Strong experience with RNA extraction, RT-qPCR, and quantitative data analysis. Expertise in cell culture and good aseptic technique. Experience performing internalization assays or related cellular uptake studies. Excellent organizational skills, autonomy, and ability to manage multiple experiments in parallel. Strong analytical mindset, attention to detail, and rigorous documentation. Ability to work effectively in a multidisciplinary, fast‑paced environment. Our Values Scientific curiosity: Ability to explore complex topics with a proactive, solution-oriented mindset and strong problem‑solving skills. Rigor and analytical mindset: Methodical approach, critical thinking when interpreting experimental data, with strong attention to detail and reproducibility. Team spirit: Close collaboration with R&D teams, respect for complementary expertise, and clear, constructive communication. Scientific integrity: Adherence to protocols, transparency in results, and a strong ethical commitment throughout the project. Adaptability: Agility in a fast‑evolving environment, ability to handle unexpected challenges, and continuous learning from both successes and failures. Passionate about translating science into impact for patients Salary: 40K – 45K depending on profile Annual individual performance bonus 100% coverage of Vélib bike subscription 60% coverage of family health insurance plan Exciting, high-impact scientific projects Supportive and dynamic work environment Small, agile team with real responsibilities from day one Modern offices, state-of-the-art equipment… and unlimited coffee #J-18808-Ljbffr