Technicien toxicologie et pharmacocinétique préclinique

General Mission

Conduct and support early toxicology and preclinical pharmacokinetic studies.

Responsibilities

• Follow study protocols provided by the Study Director.
• Contribute to the procurement of animals, consumables, and test compounds required for preclinical studies.
• Take responsibility for study preparation: prepare formulations, identify containers dedicated to the collection of biological matrices, tissues, or organs, and provide paper or electronic documentation dedicated to raw data collection and processing.
• Perform animal randomization based on body weight.
• Monitor animals during studies according to protocol requirements and verify environmental study data.
• Administer test compounds to animals in accordance with study protocol requirements and under the supervision of the Study Director.
• Collect and prepare biological matrices, tissues, and organs in accordance with study protocol requirements.
• Take responsibility for or contribute to the development of new sampling, collection, or dosing techniques while ensuring animal welfare.
• Depending on qualifications, be responsible for and contribute to the implementation of surgical techniques to meet protocol requirements and support the development of new animal models.
• Contribute to the technical support of efficacy studies or early toxicology studies.
• Process data collected during the in-life phase and format it for use by the Study Director in the preparation of study reports.
• Report activities and maintain required tools: collect all information necessary to support departmental or organizational operational metrics; record completed tasks and individual activity data using approved forms or designated software; record animal management data in the laboratory animal management software used within the department.
• Comply with and apply laboratory procedures: use laboratory animals in accordance with applicable regulations, AAALAC recommendations, and company guidelines relating to this activity; ensure the proper use of equipment.
• Support the onboarding and training of new employees.
• Contribute to the implementation of animal care, enrichment, and hygiene programs within the animal facility during weekdays, weekends, and public holidays.
• Serve as a member of the Animal Welfare Body (AWB) or the Ethics Committee.
• Contribute to or lead continuous improvement projects, benefiting from Lean methodology tools.
• Carry out activities in compliance with applicable quality procedures and with current health, safety, security, and environmental (HSSE) requirements.

Qualifications

• Skills in laboratory animal science.
• Knowledge of laboratory animal biology and animal welfare regulations.
• Knowledge of pharmacokinetics.
• Proficiency in computer tools (Word, Excel, PowerPoint, and software related to equipment operation).
• Strong written and verbal communication skills.
• Attention to detail, organizational skills, autonomy, teamwork, and dynamism.

Experience and Education

• FunctionA certification or FELASAB certification – Laboratory Animal Use and Protection – FunctionA.
• Experience in laboratory animal techniques.

Equality and Diversity

The company considers all applications equally, including those of people with disabilities, on an equal competence basis.