Postdoctoral Researcher Position – NF-κB, Proteasome, Cancer

Research Area: NF-κB Signaling | Cancer Biology | Immunology | Multiple Myeloma | Mantle Cell Lymphoma | Proteasome | Ubiquitination | Molecular Biology

The Centre d’Immunologie et des Maladies Infectieuses (CIMI-Paris) is recruiting a Postdoctoral Researcher for a 3-year fixed-term position to investigate new therapeutic strategies targeting the NF-κB pathway in multiple myeloma and mantle cell lymphoma. The project is funded by the French National Cancer Institute (INCa).

The project aims to identify and characterize new therapeutic targets regulating NF-κB activation in hematological malignancies, with a particular focus on multiple myeloma and mantle cell lymphoma.

The research will investigate:

• Ubiquitin-proteasome system and its regulatory mechanisms
• Supramolecular complexes involved in NF-κB signaling
• Bortezomib-sensitive and bortezomib-resistant cancer models
• Patient samples from individuals with multiple myeloma

The project combines molecular biology, cancer research, immunology, inflammation, cellular pharmacology, and proteomics to identify potential therapeutic strategies.

Study the molecular mechanisms regulating NF-κB activation in response to pro-inflammatory cytokines and identify potential therapeutic regulators.

Proteasome & Ubiquitination

Investigate the ubiquitin-proteasome system, proteasome-associated regulators, and their role in cancer-associated signaling.

Multiple Myeloma & Mantle Cell Lymphoma

Evaluate therapeutic targets and pharmacological compounds in multiple myeloma and mantle cell lymphoma models, including drug-resistant systems.

Explore mechanisms connecting inflammation, immune signaling, infection, and cancer biology to identify clinically relevant therapeutic opportunities.

Translational Research

Assess the relevance of experimental findings using patient samples from multiple myeloma, alongside collaborations with clinical and research partners.

Experience with several of the following techniques will be valued:

• Cell culture
• Western blotting
• CRISPR/Cas9
• Proteomics
• Flow cytometry
• Molecular and cellular biology

Experience in cancer biology, immunology, inflammation, infection, NF-κB signaling, proteasome/ubiquitination, or hematology would be particularly relevant.

Applicants should hold a PhD in one of the following areas:

• Cell Biology
• Molecular Biology
• Cancer Biology
• Pharmacology
• Related biological or biomedical disciplines

The ideal candidate should demonstrate:

• Strong scientific curiosity
• Rigorous and independent research ability
• Ability to develop and execute scientific hypotheses
• Strong interest in cancer, immunology, inflammation, or molecular signaling
• Ability to work effectively within a multidisciplinary research environment

The postdoctoral researcher will work within a multidisciplinary research environment at CIMI-Paris, with collaborations involving:

• Toulouse Cancer Research Center
• Clinical and research teams associated with Sorbonne Université

CIMI-Paris is a joint research unit affiliated with Sorbonne Université, INSERM, and CNRS, located at the Pitié-Salpêtrière campus in Paris.

What You’ll Gain

• Opportunity to work on cancer and immunology research
• Advanced experience in NF-κB signaling
• Exposure to ubiquitination and proteasome biology
• Hands-on experience with molecular and cellular techniques
• Experience with pharmacological cancer models
• Opportunity to work with patient-derived samples
• Interdisciplinary collaborati