PhD student in Biophysics
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Organisation/Company CNRS Department Institut de Biologie du Développement de Marseille Research Field Biological sciences Biological sciences » Biology Researcher Profile First Stage Researcher (R1) Application Deadline 2 Oct 2026
- 23:59 (UTC) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Jan 2027 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No
Offer Description
The research will be carried out at the IBDM (Institute of Developmental Biology of Marseille) within the “Physical approaches to cell dynamics and tissue morphogenesis (PoM)” team, and at IUSTI (University Institute of Industrial Thermal Systems) within the SOFT team. It will be co-supervised by Raphaël Clément (IBDM) and Joël Marthelot (IUSTI).
Located on the Luminy Campus, IBDM comprises approximately 220 permanent staff members, including researchers, faculty members, engineers and technicians, as well as non-permanent staff, including fixed-term contract researchers, postdoctoral researchers, PhD students and interns, distributed across 21 research teams and 11 technical platforms and services. IBDM is a joint research unit under the supervision of CNRS and Aix-Marseille University (AMU), focusing on developmental biology and associated diseases.
As the laboratories comprise members of several nationalities, proficiency in English is essential.
In Drosophila, approximately 12 hours after puparium formation, the head rapidly everts, moving from inside to outside the body within a few tens of seconds. This spectacular transformation appears to be triggered by a rapid increase in internal pressure within the pupa, but the physical and biological mechanisms that control it remain largely unknown.
The aim of this PhD project will be to understand how changes in pressure drive this extremely rapid three-dimensional reconfiguration of a tissue.
The dynamics of head eversion will be characterized by combining confocal and electron microscopy. These approaches will allow us to quantify changes in tissue shape, curvature, and thickness during eversion. Internal pressure will be measured directly in vivo and related to muscle activity and the dynamics of eversion. The mechanical properties of the tissues will also be measured to determine their role in triggering and controlling the speed of the transformation. Perturbations of muscle activity, together with mutants displaying defects in head eversion, will be used to identify the mechanisms responsible for pressure generation and the physical factors limiting eversion. Finally, the experimental data will be integrated into a biophysical model linking pressure, geometry, and tissue mechanical properties.
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