PhD thesis project
il y a 1 semaine
Context The Curie Institute Research Center is a major player in the fight against cancer. It consists of a hospital and a Research Center of more than 1000 employees with a strong international objective. The “Immunity and Cancer” unit (U932) at Institut Curie is composed of 10 research teams, including the “Innate Immunity” team led by Nicolas Manel. As all researchers at Institut Curie, team members have access to 19 state‑of‑the‑art technology platforms, research support services and a training catalogue including scientific and soft skills. 4Dcell is an innovative French start‑up that aims to revolutionize in vitro pharmacological testing while reducing the use of live animal testing. Its cell culture consumables allow for better control of the cellular microenvironment and are used to design model organoids that facilitate the discovery of new drugs (immuno‑oncological treatments, heart failure, liver diseases, neurological disorders). PhD students will benefit from an interdisciplinary, international research environment at the interface between fundamental research and applications for the benefit of society. Objectives Study the cellular and molecular ageing of the in vitro “SmartHeart” cardiac organoid developed by 4Dcell in collaboration with Prof. Jean‑Sébastien Hulot’s team at the Paris Cardiovascular Research Center, using genetic, biophysical or pharmacological perturbations. Build a non‑destructive biological clock for the SmartHeart. Model the experimental data and behaviour of the SmartHeart to generate a digital twin. Use this digital twin to define and perform in‑vitro testing of pharmacological interventions having a positive or negative impact on the biological ageing of the SmartHeart. Job specifications The PhD student will carry out his / her thesis under the supervision of Dr Nicolas Manel and will be seconded 70% of his / her time to the 4Dcell site in Montreuil (93100), under the co‑direction of Dr Christophe Pannetier, Scientific Director. Training, experience and skills required Master’s degree in Cellular or Molecular Biology and/or Computational Biology. Past experience in a research laboratory in molecular or cellular biology. Ideally, a profile with previous internship experience in cardiomyocyte culture maintenance and differentiation of induced pluripotent stem cells (iPSCs) (cell types : cardiomyocytes, fibroblasts, endothelial cells, etc.). Programming in R, Python and/or Matlab, data processing. Problem solving mindset. Motivation for wet‑lab experimentation. Ability to work in a team. Excellent communication skills with diverse audiences are essential. Excellent level of English. All our opportunities are open to people with disabilities. Contract information Type of contract: Doctoral Contract Starting date: Between September and December 2024 Contract duration: 3 years Working time: Full time Remuneration According to the current grids. Benefits Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance. Location: Institut Curie – Paris. Contact Please send your CV, a letter of motivation and the contact (Name, Phone, Email and description of the link with the candidate) for two references to the recruitment team. Publication date: 03 / 07 / 2024 Deadline for application: 30 / 09 / 2024 (until the position is filed). Institut Curie is an inclusive, equal opportunity employer and is dedicated to the highest standards of research integrity. #J-18808-Ljbffr
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