PhD thesis project
il y a 1 jour
Context The Curie Institute Research Center is a major player in the fight against cancer. It consists of a hospital and a Research Center of more than 1000 employees with a strong international objective. The “Immunity and Cancer” unit (U932) at Institut Curie is composed of 10 research teams, including the “Innate Immunity” team led by Nicolas Manel. As all researchers at Institut Curie, team members have access to 19 state‑of‑the‑art technology platforms, research support services and a training catalogue including scientific and soft skills. 4Dcell is an innovative French start‑up that aims to revolutionize in vitro pharmacological testing while reducing the use of live animal testing. Its cell culture consumables allow for better control of the cellular microenvironment and are used to design model organoids that facilitate the discovery of new drugs (immuno‑oncological treatments, heart failure, liver diseases, neurological disorders). PhD students will benefit from an interdisciplinary, international research environment at the interface between fundamental research and applications for the benefit of society. Objectives Study the cellular and molecular ageing of the in vitro “SmartHeart” cardiac organoid developed by 4Dcell in collaboration with Prof. Jean‑Sébastien Hulot’s team at the Paris Cardiovascular Research Center, using genetic, biophysical or pharmacological perturbations. Build a non‑destructive biological clock for the SmartHeart. Model the experimental data and behaviour of the SmartHeart to generate a digital twin. Use this digital twin to define and perform in‑vitro testing of pharmacological interventions having a positive or negative impact on the biological ageing of the SmartHeart. Job specifications The PhD student will carry out his / her thesis under the supervision of Dr Nicolas Manel and will be seconded 70% of his / her time to the 4Dcell site in Montreuil (93100), under the co‑direction of Dr Christophe Pannetier, Scientific Director. Training, experience and skills required Master’s degree in Cellular or Molecular Biology and/or Computational Biology. Past experience in a research laboratory in molecular or cellular biology. Ideally, a profile with previous internship experience in cardiomyocyte culture maintenance and differentiation of induced pluripotent stem cells (iPSCs) (cell types : cardiomyocytes, fibroblasts, endothelial cells, etc.). Programming in R, Python and/or Matlab, data processing. Problem solving mindset. Motivation for wet‑lab experimentation. Ability to work in a team. Excellent communication skills with diverse audiences are essential. Excellent level of English. All our opportunities are open to people with disabilities. Contract information Type of contract: Doctoral Contract Starting date: Between September and December 2024 Contract duration: 3 years Working time: Full time Remuneration According to the current grids. Benefits Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance. Location: Institut Curie – Paris. Contact Please send your CV, a letter of motivation and the contact (Name, Phone, Email and description of the link with the candidate) for two references to the recruitment team. Publication date: 03 / 07 / 2024 Deadline for application: 30 / 09 / 2024 (until the position is filed). Institut Curie is an inclusive, equal opportunity employer and is dedicated to the highest standards of research integrity. #J-18808-Ljbffr
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Paris, France France Life Imaging Temps pleinJob Title: PhD thesis on AI for the segmentation of biomarkers of cardiovascular Risk on 3D-CTContext and Mission: Ischemic heart disease, heart failure, and atrial fibrillation are conditions responsible for a very high cardiovascular mortality. The cardiac scanner is an imaging method that is increasingly used in these conditions, even if its analysis...
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Thesis offer – Laboratory of Molecular Electrochemistry
il y a 1 jour
Paris, France Dim Materre Temps pleinThesis offer – Laboratory of Molecular ElectrochemistryThe MER team of the LEM , member of MaTerRE, is looking for a PhD student to do a thesis in electrochemistry!The thesis will aim to understand the electrochemical reactivity coupled to the proton of metal oxides by rationalizing the competition between the reversible insertion of the proton, the...
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PhD opening in Sustainability
il y a 24 heures
Paris, France KEDGE BS Temps pleinKEDGE Business School est une école de management française de référence, présente sur 4 campus en France (Paris, Bordeaux, Marseille et Toulon), 2 en Chine (Shanghai et Suzhou), 2 en Afrique (Sénégal et Côte d'Ivoire) et 6 campus associés (Avignon, Bastia, Bayonne, Mont-de-Marsan, Dakar, Abidjan). KEDGE BS propose une offre de 38 formations en...
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PIMM thesis offer
il y a 1 jour
Paris, France Dim Materre Temps pleinOverviewThe PIMM, member of MaTerRE, is looking for a PhD student to carry out a thesis on innovative and eco-responsible processes for the implementation of lithium-ion batteries.ObjectivesThe objective will be to develop methods of manufacturing third-generation lithium-ion batteries by molten extrusion process, that are more productive, environmentally...
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PhD in AI for Cardio Biomarker Segmentation on 3D CT
il y a 24 heures
Paris, France France Life Imaging Temps pleinA leading medical imaging company is seeking a candidate for a PhD thesis on AI for the segmentation of cardiovascular biomarkers. The role involves collaboration with Siemens Healthineers and academic centers to develop and validate AI methods in medical imaging. Candidates should have skills in programming (C++, Python), image processing, and a keen...
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Phd Position F/m Multilingual and Cross-cultural
il y a 2 semaines
Paris, France Inria Temps pleinLe descriptif de l’offre ci-dessous est en Anglais_ **Type de contrat **:CDD **Niveau de diplôme exigé **:Bac + 5 ou équivalent **Fonction **:Doctorant **Contexte et atouts du poste**: **Mission confiée**: **PhD topic** In particular, this Ph.D. thesis aims to detect formal and informal logical fallacies in a multilingual corpus of political...
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Thesis study of Post-quantum Cryptography Publick
il y a 5 jours
Paris, France Orange Temps pleinYour role is to conduct a thesis on "A study of post-quantum public key schemes." Scientific objective, results, and challenges: The objective is to have the most efficient signature schemes possible (in terms of signature and key size, key and signature generation time). Finally, another objective is to provide theoretical security proofs related to the...
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Paris, France France Life Imaging Temps pleinContexte et mission : OVERVIEW We are looking for a candidate for a science thesis in Cardiovascular Imaging and Pharmacology. Our laboratory is interested in the non‑destructive imaging analysis of energy metabolism and vascularization. We have recently introduced a new non‑invasive imaging technique to simultaneously study these two phenomena and their...
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Paris, France ICube Temps pleinContext Pulmonary and muscle tissues involved in respiratory function can be affected in various diseases (COPD, neuromuscular diseases, CoViD…). Quantitative MRI has become a key tool for studying neuromuscular diseases, but it mainly focuses on static limb muscles. Imaging the lungs and respiratory muscles is challenging due to motion and low MR signal...
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IT Innovation Funding Consultant
il y a 1 jour
Paris, France PNO Innovation Temps pleinA leading innovation consultancy based in France is seeking an IT Consultant to support digital innovation clients. The role involves analyzing R&D projects in IT and deep tech, drafting proposals, and contributing to innovation strategies. Candidates must hold a PhD and exhibit strong analytical and technical writing skills in French. The position offers a...
