PhD Position in Immunology

il y a 4 jours


Paris, Île-de-France Institut Curie Temps plein
About the Position

We are seeking a highly motivated and talented PhD candidate to join our team at the Institut Curie Research Center in Paris, France. The successful candidate will be part of a dynamic and interdisciplinary research environment, working on a CIFRE thesis grant with Sanofi.

The project focuses on deciphering the dialogue between stromal cells and immune cells in cancer, with a specific emphasis on cancer-associated fibroblasts (CAF) and their role in T-cell exclusion. The candidate will have the opportunity to explore human tumor lesions using multiplex imaging and spatial transcriptomics, and to test the effects of CAF targets on T-cell dynamics and tumor lysis using CRISPR and a human tumor spheroid/CAF system.

The ideal candidate will have a strong background in immunology, molecular and cellular biology, or biotechnology, and excellent analytical and synthesis skills. Experience in image analysis, transcriptomic analysis, or molecular biology would be an asset.

Responsibilities
  1. Explore human tumor lesions using multiplex imaging and spatial transcriptomics to identify CAF-specific genes involved in T-cell exclusion.
  2. Test the effects of these CAF targets on T-cell dynamics and tumor lysis using CRISPR and a human tumor spheroid/CAF system.
  3. Evaluate in preclinical models the therapeutic potential of therapies targeting fibroblasts and checkpoint blockade.
Requirements
  • M2 in immunology, molecular and cellular biology, or biotechnology.
  • Culture of primary cells and tumor cell lines.
  • Flow cytometry.
  • French (professional) required.
  • Animal experimentation.
  • Knowledge of human immunology, oncology, and immunotherapy.
  • Scientific rigor and excellent analytical and synthesis skills.
  • Team spirit and dynamic personality with a passion for innovation and problem-solving.
What We Offer
  • PhD CIFRE contract of 3 years.
  • Starting date: as soon as possible.
  • Duration: 3 years.
  • Working time: full time.
  • Remuneration: according to the current grids.
  • Benefits: collective catering.
  • Location of the position: Paris, 26 rue d'Ulm.


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