PhD Position in Immunology
il y a 4 jours
We are seeking a highly motivated and talented PhD candidate to join our team at the Institut Curie Research Center in Paris, France. The successful candidate will be part of a dynamic and interdisciplinary research environment, working on a CIFRE thesis grant with Sanofi.
The project focuses on deciphering the dialogue between stromal cells and immune cells in cancer, with a specific emphasis on cancer-associated fibroblasts (CAF) and their role in T-cell exclusion. The candidate will have the opportunity to explore human tumor lesions using multiplex imaging and spatial transcriptomics, and to test the effects of CAF targets on T-cell dynamics and tumor lysis using CRISPR and a human tumor spheroid/CAF system.
The ideal candidate will have a strong background in immunology, molecular and cellular biology, or biotechnology, and excellent analytical and synthesis skills. Experience in image analysis, transcriptomic analysis, or molecular biology would be an asset.
Responsibilities- Explore human tumor lesions using multiplex imaging and spatial transcriptomics to identify CAF-specific genes involved in T-cell exclusion.
- Test the effects of these CAF targets on T-cell dynamics and tumor lysis using CRISPR and a human tumor spheroid/CAF system.
- Evaluate in preclinical models the therapeutic potential of therapies targeting fibroblasts and checkpoint blockade.
- M2 in immunology, molecular and cellular biology, or biotechnology.
- Culture of primary cells and tumor cell lines.
- Flow cytometry.
- French (professional) required.
- Animal experimentation.
- Knowledge of human immunology, oncology, and immunotherapy.
- Scientific rigor and excellent analytical and synthesis skills.
- Team spirit and dynamic personality with a passion for innovation and problem-solving.
- PhD CIFRE contract of 3 years.
- Starting date: as soon as possible.
- Duration: 3 years.
- Working time: full time.
- Remuneration: according to the current grids.
- Benefits: collective catering.
- Location of the position: Paris, 26 rue d'Ulm.
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