Cell Line Development Expert

il y a 1 semaine

SoisysurSeine, Île-de-France Kyron Temps plein

Description Poste

We are seeking a highly skilled and entrepreneurial-minded CHO cell line development expert to join our team at Kyron. As a key member of our R&D team, you will be responsible for the execution of feasibility studies for industry partners, testing different genetic integration strategies in CHO cells, and optimizing growth conditions.

Roles and Responsibilities:


• Be the driving force behind the development of stable mammalian cell lines expressing key therapeutic proteins of interest (both transiently and stably)

• Lead the optimization and development of CHO cell medium for engineered cell lines, coordinating with third parties where required

• Adapt CHO cells to serum-free and suspension growth

• Explore and optimize gene expression in both CHO and HEK cells (testing different promoters, UTR's, etc)

• Optimize & scale up growth of different CHO cell lines

• Quality reporting of cell banks

• Contribute to set up and development of in-house analytical studies

• Take on managerial responsibilities as the team grows, contributing to growth and recruitment of a fast-growing R&D team

Description Profil

Skills and Requirements:


• Minimum 3 years relevant industry experience working with cell line development

• PhD in cell and molecular biology, biochemistry, biological engineering, or other life science discipline (exceptional Masters students with extensive industry experience will be considered)
• Experience in suspension CHO/HEK cell line development; Vector design/Cloning; Stable and transient transfections; Single cell cloning; Clone selection (ELISA/Octet); Research Cell Banking (RCB) generation; Stability Assessment Studies; Genetic characterization methods (qPCR, whole genome sequencing)

• Experience leading projects or project sub-teams and/or managing contract research relationships

• Excellent planning and organization skills

• Team player who can deliver projects in a timely manner, yet work independently when needed

• Someone who wants to push the boundaries of scientific knowledge and tackle things they have never done before (or no one has)

• A creative thinker with an entrepreneurial, problem-solving mindset

• Fluency in English

Bonus Skills:


• Knowledgeable about GMP and regulatory requirements

• Postdoctoral studies

• Experience working with glycoproteins and/or the protein secretory pathway

• Mass spectrometry experience

• Patent inventor

• Experience working with plant and yeast recombinant expression systems

• French language

Poste Proposé

Intitulé du Poste Proposé
– Senior Scientist – CHO cell line development

Poste basé à Paris

Secteur d'activité : Biotechnology

Nature du contrat : CDI

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