CHO Cell Line Development Expert

il y a 2 semaines


SoisysurSeine, Île-de-France Kyron Temps plein

Job Description:

We are seeking a highly skilled CHO cell line development expert to join our team at Kyron.bio in Paris. The ideal candidate will have a strong industrial grounding and excellent leadership and communication skills.

Roles and Responsibilities:

  • Be the driving force behind the development of stable mammalian cell lines expressing key therapeutic proteins of interest.
  • Lead the optimisation and development of CHO cell medium for engineered cell lines, coordinating with third parties where required.
  • Adapt CHO cells to serum-free and suspension growth.
  • Explore and optimise gene expression in both CHO and HEK cells.
  • Optimise & scale up growth of different CHO cell lines.
  • Quality reporting of cell banks.
  • Contribute to set up and development of in house analytical studies.
  • Take on managerial responsibilities as the team grows.

Requirements:

  • Minimum 3 years relevant industry experience working with cell line development.
  • PhD in cell and molecular biology, biochemistry, biological engineering, or other life science discipline.
  • Experience in suspension CHO/HEK cell line development; Vector design/Cloning; Stable and transient transfections; Single cell cloning; Clone selection (ELISA/Octet); Research Cell Banking (RCB) generation; Stability Assessment Studies; Genetic characterization methods (qPCR, whole genome sequencing).
  • Experience leading projects or project sub teams and/or managing contract research relationships.
  • Excellent planning and organisation skills.
  • Team player who can deliver projects in a timely manner, yet work independently when needed.
  • Fluency in English.

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