CHO Cell Line Development Expert
il y a 2 semaines
Job Description:
We are seeking a highly skilled CHO cell line development expert to join our team at Kyron.bio in Paris. The ideal candidate will have a strong industrial grounding and excellent leadership and communication skills.
Roles and Responsibilities:
- Be the driving force behind the development of stable mammalian cell lines expressing key therapeutic proteins of interest.
- Lead the optimisation and development of CHO cell medium for engineered cell lines, coordinating with third parties where required.
- Adapt CHO cells to serum-free and suspension growth.
- Explore and optimise gene expression in both CHO and HEK cells.
- Optimise & scale up growth of different CHO cell lines.
- Quality reporting of cell banks.
- Contribute to set up and development of in house analytical studies.
- Take on managerial responsibilities as the team grows.
Requirements:
- Minimum 3 years relevant industry experience working with cell line development.
- PhD in cell and molecular biology, biochemistry, biological engineering, or other life science discipline.
- Experience in suspension CHO/HEK cell line development; Vector design/Cloning; Stable and transient transfections; Single cell cloning; Clone selection (ELISA/Octet); Research Cell Banking (RCB) generation; Stability Assessment Studies; Genetic characterization methods (qPCR, whole genome sequencing).
- Experience leading projects or project sub teams and/or managing contract research relationships.
- Excellent planning and organisation skills.
- Team player who can deliver projects in a timely manner, yet work independently when needed.
- Fluency in English.
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