Lead Scientist in CHO Cell Line Innovation

il y a 4 semaines


SoisysurSeine, Île-de-France Kyron Temps plein

Position Overview

We are looking for an experienced and innovative Senior Scientist specializing in CHO cell line development. This role involves conducting feasibility assessments for industry collaborations, experimenting with various genetic integration techniques in CHO cells, and refining growth parameters. The successful candidate will possess a strong industrial background, exceptional leadership capabilities, and the ability to communicate effectively.

Key Responsibilities:


• Spearhead the creation of stable mammalian cell lines that express crucial therapeutic proteins, both transiently and stably.

• Oversee the optimization and formulation of CHO cell culture media for engineered cell lines, liaising with external partners as necessary.

• Adapt CHO cells for serum-free and suspension growth conditions.

• Investigate and enhance gene expression in CHO and HEK cells by testing various promoters and UTRs.

• Optimize and scale the growth of diverse CHO cell lines.

• Ensure quality reporting of cell banks.

• Contribute to the establishment and advancement of in-house analytical studies.

• Assume managerial duties as the team expands, aiding in the growth and recruitment of a dynamic R&D team.

Candidate Profile

Required Skills and Qualifications:


• At least 3 years of relevant industry experience in cell line development.

• PhD in cell and molecular biology, biochemistry, biological engineering, or a related life science field (exceptional candidates with a Master's degree and significant industry experience may be considered).

• Proficient in suspension CHO/HEK cell line development; vector design and cloning; stable and transient transfections; single-cell cloning; clone selection (ELISA/Octet); research cell banking (RCB) generation; stability assessment studies; and genetic characterization techniques (qPCR, whole genome sequencing).

• Experience in leading projects or managing project sub-teams and/or overseeing contract research collaborations.

• Strong planning and organizational skills.

• A collaborative team player capable of delivering projects on time while also working independently when required.

• A visionary who is eager to expand the frontiers of scientific knowledge and tackle unprecedented challenges.

• A creative thinker with an entrepreneurial spirit and a problem-solving approach.

• Proficiency in English.

Preferred Skills:


• Familiarity with GMP and regulatory standards.

• Postdoctoral research experience.

• Background in working with glycoproteins and/or the protein secretory pathway.

• Experience in mass spectrometry.

• Patent inventor status.

• Experience with plant and yeast recombinant expression systems.

• Proficiency in French.

Job Title:
– Senior Scientist – CHO Cell Line Development

Employment Type:
Permanent



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