Stage M2: The Role of Mirna in Myogenic Cell

il y a 22 heures

FontenayauxRoses, France IRSN Temps plein

**Intitulé du poste**:
Stage M2: The role of miRNA in myogenic cell communication in response to ionizing radiation H/F

**Type de contrat**:
STAGE

**Statut**:
Non cadre

**Disponibilité du poste**:
13/01/2025

**Localisation du poste**:
Fontenay-aux-Roses

**Environnement / Organisation / Contexte**:
Radiotherapy remains unavoidable in most cancer treatments. However, its effectiveness is accompanied by side effects due to the irradiation of healthy cells adjacent to cancer. Thus, understanding the biological consequences responsible for the damage of healthy tissue is essential for the development of methods to prevent, mitigate and treat toxicity induced by exposure to ionizing radiation.
Skeletal striated muscle, which accounts for up to 40% of body mass, is often included in the treatment field. Although the macroscopic consequences of radiotherapy on the muscle tissue are well studied, little is known about the molecular mechanisms involved in maintaining highly coordinated cellular metabolism and muscular tissue homeostasis, such as intercellular communication between the different myogenic cells that make up muscle.

This M2 internship for 6 months is available from January 2025 in the Laboratory of Radiobiology of Accidental Exposures (LRAcc) within the Department of Research in Radiobiology and Regenerative Medicine (SERAMED) of the Department of Health of the Institute of Radiation Protection and Nuclear Safety (IRSN).

**Mission**:
Intercellular communication is vital for a tissue, enabling it to respond to a stress, such as irradiation, and to restore tissue homeostasis. To this end, cells can use microRNAs (miRNAs) as a communication mean. Their main role is to regulate the expression of certain genes in target cells.

**Profil recherché**:
We are seeking for highly motivated Master 2 student in biology / health sciences, with good knowledge in cellular and molecular biology.

**Télétravail**:
Non

**Diversité**:
**La diversité est une des composantes de la politique RSE, RH et Qualité de Vie au Travail à l’IRSN.**

**L'IRSN conduit une politique active depuis de nombreuses années en faveur de l'égalité des chances au travail et l'emploi des personnes handicapées. Si vous êtes en situation de handicap, n'hésitez pas à nous faire part de vos éventuels besoins spécifiques afin que nous puissions les prendre en compte.**

**Localisation du poste**:
**Localisation du poste**:
Europe, France, Ile-de-France, Hauts-de-Seine (92)

**Langues**:

- Français (3- Niveau avancé)
- Anglais (2- Niveau professionnel)

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