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Postdoctoral Research Fellowship
il y a 23 heures
Institut Laue-Langevin (ILL) - operates Europe‘s leading research facility for basic research with neutrons in Grenoble (France). The passion for progress and technology unites us and makes innovation in science and research possible every day. Let‘s work together to change our society and our world for the better.
**Poste et missions**:
We are offering a 3-year full-time postdoctoral research fellowship focused on advancing structural biology through single-crystal neutron diffraction techniques. This position focuses on visualizing critical hydrogen atoms in carbohydrate-binding proteins and their complexes using neutron diffraction along with complementary structural biology methods.
This research fellow position is part of the EU-funded Marie Skłodowska-Curie (MSCA) COFUND research project AMBER, Advanced Multiscale Biological imaging using European Research infrastructures, which aims to address scientific and sectoral gaps in biological imaging ranging from molecular, through cellular, to tissue, organ and organism levels of organisation, and is coordinated by the LINXS Institute of advanced Neutron and X-ray Science. Around 15 postdocs will be recruited in the fifth call 2026, with each fellowship lasting 36 months.
**Context**
This 3-year research fellowship is part of the EU Marie Skłodowska-Curie (MSCA) COFUND research project AMBER, Advanced Multiscale Biological imaging using European Research infrastructures. This project will address scientific and sectoral gaps in biological imaging ranging from molecular, through cellular, tissue, organ and organism levels of organisation, and is coordinated by the LINXS Institute of advanced Neutron and X-ray Science.
AMBER has six core partners: Lund University/MAX IV, Sweden, the European Spallation Source (ESS), Sweden, the European Molecular Biology Laboratory (EMBL), the Institut Laue-Langevin (ILL), France, the International Institute of Molecular Mechanisms and Machines, (IMOL), Poland, and the Leicester Institute of Structural and Chemical Biology, United Kingdom. For more information about AMBER.
**Description of the Project**
Protein-carbohydrate interactions are involved in the first step of many infectious processes. Many pathogens (bacteria, viruses and fungi) recognize sugar epitopes present in glycolipids and glycoproteins on host tissue as the first step of infection. On the other hand, many human lectins such as the ones of the dendritic cells, recognize fragments of bacterial cell wall polysaccharide as the first stage of the innate immunity process. A detailed structural knowledge of the interactions may serve as the basis for the design of new inhibitors that could act as alternative strategies to antibiotic treatment in some infections. This call is for a 3-year full-time research fellowship project, focused on using single-crystal neutron diffraction techniques in combination with other structural biology techniques, in order to visualize important hydrogen atoms in carbohydrate-binding proteins and their complexes. At the Institut Laue-Langevin (ILL), the world’s most powerful steady state neutron source, advanced beamlines for neutron crystallography are available (LADI and DALI) along with dedicated laboratories for the production of fully deuterated proteins (D-Lab).
Researchers from the Glyco Alps network at the Institut de Biologie Structurale (IBS) and Centre de Recherches sur les Macromolécules Végétales (CERMAV) have expertise in production of recombinant human and microbial lectins, respectively. In addition, certain saccharides (and their analogs) can be produced in deuterated form via a synthetic biology approach, in collaboration with CERMAV (see Gajdos et al., 2021, Glycobiology 31, 151; Gajdos et al., Nat. Commun. 13, 194). Moreover, the Partnership for Structural Biology (PSB) on the European Photon and Neutron (EPN) Science campus provides a unique environment for state-of-the-art integrated structural biology with access to many technical platforms for sample production, biophysical characterization and structure determination.
Your work at the ILL will focus on using single-crystal neutron diffraction techniques in combination with other structural biology techniques, in order to visualize important hydrogen atoms in carbohydrate-binding proteins and their complexes.
**Name and working place of the Principal investigator**
Matthew Blakeley, Large-Scale Structures group, Institut Laue-Langevin, Grenoble, France, is responsible for the neutron macromolecular crystallography beamlines LADI and DALI. His research uses single-crystal neutron diffraction in combination with other structural biology techniques for studies of biological macromolecular structure and function, typically health/disease related and with a particular focus on structure-based drug design.
**Mobilité géographique**:
- Pas de déplacement
**Profil**:
- Minimum requirements
- PhD in structural biology/chemistry, with excellent knowledge of b
