Technician, Nucleotide Manufacturing

**DNA Script** DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using enzymatic DNA synthesis (EDS) technology. The company aims at accelerating innovation in life science and technology through the decentralization of rapid, on demand and high-quality DNA synthesis. DNA Script's approach leverages nature's billions of years of evolution in synthesizing DNA to set a new standard for customizing nucleic acid synthesis thus accelerating discovery in genetics, genomics, and synthetic biology. Discovery disciplines with profound impacts upon humanity such as biopharma, translational genetics and even molecular information storage all start with synthetic DNA. The company has recently initiated the commercialization of its first EDS powered platform, the SYNTAX system. To date, DNA Script has raised over $315M of financing, with leading investors such as Coatue Management, Fidelity Management and Research, Catalio Capital Management, Casdin Capital, LSP, Bpifrance Large Ventures, Danaher, Illumina Ventures, Agilent, Merck Ventures, Sofinnova Partners, Kurma Partners, T Rowe Price, Baillie Gifford and Eurazeo. DNA Script also partners on technology and product development with leading organizations such as DARPA, IARPA, Moderna Therapeutics, GE Research, Illumina, the Broad Institute, Harvard University, Institut Pasteur and the French Department of Defense. DNA Script has its research and manufacturing facilities headquartered in Paris, France, and is in the process of expanding its commercial and development teams in South San Francisco. **Opportunity and Challenges**: We are looking to assemble a team of best-in-class, innovative and passionately eager people. We want to gather their talents and skills to achieve one goal: unlock the power of "DNA-write." We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our DNA On Demand platform not only has the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results. This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impacts across biological sciences. **The Role** DNA Script is actively searching for a Manufacturing Technician who will be primarily responsible for working with the nucleotide production team to assist in the in-house production of nucleotides, one of the key reagents of DNA Script's technology. Under general supervision and following written work instructions, your task will be to synthesize and purify nucleosides/nucleotides and their derivatives, as well as perform other assigned laboratory tasks. You will perform quality analysis and purifications using high performance liquid chromatography (HPLC) as well as flash chromatography (FC) while maintaining detailed documentation of all work processes. This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impact across biological sciences. The position will be based in le Kremlin Bicêtre, France. **Responsibilities**: - Manufacturing and dilution of nucleotides according to work instructions (WI) and batch manufacturing record (BMR). - Perform nucleotide manufacturing, dilutions, and logistics planning and other tasks as necessary in a laboratory environment - Execute tasks under approved SOPs, document production using batch records and contribute to improving overall quality in operations. - Maintain detailed and good manufacturing documentation of all work processes. - Perform other laboratory duties as assigned by the team supervisor. - Participate in a chemistry manufacturing team meeting and present a technical report. - Maintain the safety practices of the laboratory. - Prepare buffers, solutions following approved protocols, including the use and safe handling of hazardous chemicals, data input and record keeping. - Use approved analysis techniques to characterize and ensure the quality of products. - Work with supply chain team and our ERP (NetSuite) to follow up work orders. - Maintain finished goods inventory, work in process and raw materials; recommend material orders as needed to maintain stocks for production - Monitor, qualify, and maintain calibration of laboratory instrumentation used for manufacturing. - Participate in planning activities pertaining to kit production - Help in writing all BMR process improvements procedures. - Procure and receive materials to support nucleotide manufacturing operation. - Work under the supervision of nucleotide manufacturing management. **Experience**: - Bachelor's degree in Chemistry, Chemical Enginieering, Biology, Biochemistry, or related field. - 1-3 years of experience working with synthetic organic chemistry techniques, including but not limited to laboratory skills, in