Master internship: Quantitative imaging of phase thermodynamics in cells with Brillouin microscopy

il y a 5 jours

Montpellier, Occitanie, France France-BioImaging Temps plein

Organization:
Institut Lumière Matière

Location:
Institut Lumière Matière, Rue Ada Byron, Villeurbanne, France

Send CV, Publications, Summary And References To
Thomas Dehoux at

Position Information
Biomolecular condensates are membrane-less compartments essential for cellular organization. While their formation is normally reversible, certain liquid-to-solid transitions can lead to irreversible aggregation associated with aging and neurodegenerative diseases. Understanding the physical mechanisms driving these transitions requires quantitative tools capable of probing viscoelastic properties directly in living cells.

Brillouin light scattering (BLS) microscopy
offers a promising solution by measuring acoustic responses at subcellular scales. Our team has already demonstrated mechanical contrasts between nuclear condensates and their environment in live cells. This internship aims to
deepen these observations by developing a stimulated BLS approach
to accelerate acquisition and enable real-time monitoring of condensate formation, including pathogenic variants linked to neurodegeneration.

Missions

Under Thomas Dehoux's supervision, the student will have to:

  • Participate in the development and assembly of a stimulated Brillouin light scattering (BLS) microscope,
  • Validate and characterize the instrument on test samples before biological experiments,
  • Perform live-cell imaging experiments using inducible systems to follow condensate formation at different aggregation stages,
  • Analyze and process acoustic and microscopy data using Python (signal processing, quantitative analysis),
  • Implement theoretical modelling to interpret viscoelastic properties measured in cells,
  • Collaborate with biology engineers for cell culture, maintenance, and preparation of samples,
  • Work closely with the project supervisors (T. Dehoux and an engineer dedicated to the project).

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