Senior Executive Assistant

Cyllene Therapeutics is a clinical-stage biotechnology company developing next-generation DNA medicines for the treatment of prevalent chronic and severe neurological disorders. We have developed our proprietary HERMES (Herpes-based Modular Expression System) platform that utilizes non-replicative herpes simplex virus type 1 (nrHSV-1) vectors engineered to deliver site-specific long-lasting therapies directly to target neurons while avoiding systemic exposure. Our lead product candidate, EG110A, has shown favorable safety and efficacy interim results in our first-in-human trial currently ongoing in four U.
S. sites in patients with neurogenic detrusor overactivity (NDO)-related incontinence following spinal cord injury. We believe our HERMES platform has the potential to overcome key limitations of conventional gene therapy approaches, including limited payload capacity, immunogenicity, off-target effects, challenges associated with repeat administration and high manufacturing costs, thereby providing us with potential opportunities to grow our pipeline of product candidates. Our second product candidate, EG142A, has now demonstrated encouraging preclinical activity in a series of animal models in different forms of chronic pain.

Job Description
We are seeking an experienced and highly capable Senior Executive Assistant to support our CEO, the CFO and members of the Executive Leadership Team of Cyllene Tx, a fast-growing, international biotechnology company. This is a highly impactful role, offering the opportunity to work closely with senior leadership in a dynamic environment where priorities evolve and operational excellence is essential. The successful candidate will act as a trusted partner to the CEO and CFO, and senior executives, ensuring seamless coordination of complex schedules, international travel, executive meetings and day-to-day priorities. Beyond traditional executive assistance, we are looking for a proactive, resourceful and confident professional who anticipates needs, takes ownership, exercises sound judgment and brings structure and efficiency to a growing organization. The role requires a high degree of autonomy, adaptability and organizational maturity, as well as the ability to navigate changing priorities with professionalism and composure. Main responsibilities include: Executive calendar and priority management
• Proactively manage the CEO's & CFO’s complex and evolving calendar and coordinate schedules across the Executive Leadership Team.
• Anticipate scheduling conflicts, assess competing priorities and recommend effective solutions.
• Optimize executive time by ensuring that meetings and commitments are aligned with business priorities.
• Coordinate high-level meetings with board members, investors, strategic partners and external stakeholders.
• Adapt efficiently to last-minute changes while maintaining a structured and reliable approach.
• Ensure ComEx members are appropriately prepared for meetings, with relevant documentation and logistical arrangements. International travel and logistics
• Support travel arrangements for the CEO & CFO and the Leadership Team members, including flights, hotels, ground transportation, reservations and detailed itineraries.
• Coordinate complex international and multi-destination trips across different time zones.
• Anticipate logistical constraints, travel disruptions and potential contingencies.
• Respond effectively to unexpected changes and identify practical alternatives.
• Manage reservations and associated administrative follow-up, including expenses and invoices.
• Ensure a smooth and efficient travel experience with minimal executive involvement. Anticipation, problem-solving and operational excellence
• Anticipate CEO’s & CFO’s needs, identify potential challenges and proactively propose solutions.
• Take ownership of operational matters and resolve them independently when appropriate.
• Exercise sound judgment when managing competing priorities or evolving requirements.
• Continuously improve executive support processes, workflows and organizational efficiency.
• Act as a dependable point of contact, ensuring appropriate follow-through and timely execution.
• Handle confidential and sensitive information with the highest level of discretion. Executive support and special assignments
• Handle sensitive correspondence and communications when required.
• Support selected special projects and ad hoc assignments as requested by the CEO.
• Liaise professionally with senior stakeholders, investors, board members and external partners.
• Provide responsive and solution-oriented support during key business milestones and periods of increased activity. Key

Qualifications:

Education:
Bachelor's or Master's degree in Executive Assistant, business administration. Professional

experience:
• Significant experience in executive assistance, ideally including direct support to a CEO, President or C-suite executives in small and fast-growing companies/biotech.
• Demonstrated success in a dynamic, international corporate environment.
• Proven ability to support multiple senior executives and coordinate complex priorities.
• Strong digital literacy and ability to leverage modern productivity tools appropriately.
• Previous experience in biotechnology, pharmaceuticals, life sciences, investment banking, private equity or high-growth technology companies would be an advantage. Soft

skills:
• Excellent communication skills
• Proactivity & Anticipation
• Adaptability & Resilience
• Assertiveness
• Discretion, Confidentiality & Reliability Languages: English (spoken and written) Cyllene Therapeutics is an equal opportunity employer. We welcome applicants of all backgrounds and do not discriminate on the basis of race, color, religion, gender, sexual orientation, gender identity, national origin, age, disability or any other protected characteristic.