Study Engineer

Structure d'accueil Le Centre de recherche de l’Institut Curie Premier centre français de recherche et de lutte contre le cancer, l'Institut Curie associe un centre de recherche de renommée internationale et un hôpital de pointe. Il offre un environnement d’excellence, où les expertises se mêlent autour de valeurs communes : bienveillance, humanité, ouverture, partage, efficacité, innovation, solidarité et engagement. Missions Activités principales Team “Mechanisms of Repression by Polycomb Group Proteins” Our research team aims to understand the principles that govern gene regulation by the highly conserved family of chromatin modifiers known as Polycomb proteins, from the biochemical to the cellular and organismal levels. We are affiliated with the Institut Curie Research Center’s Genetics and Developmental Biology Unit (Inserm U934/CNRS UMR3215). https://institut-curie.org/team/margueron Missions
• Perform CRISPR-based genetic screens coupled to single cell transcriptomics.
• Engineer various stem cell models (iPS, ES) by genome editing and characterize their transcriptomic and epigenomic properties.
• Conduct biochemical studies of novel Polycomb-associated proteins.
• Participate in all common tasks such as equipment maintenance, renewing stocks, student training, etc. Activities
• Cloning
• Library preparation (RNA-seq, CUT&RUN-seq, etc.)
• Protein expression and purification, protein pulldowns, Western blot
• Maintenance and differentiation of various stem/progenitor cells
• Lentiviral transduction, transfection
• FACS sorting
• Proliferation and differentiation assays
• Interpretation, synthesis and reporting of results Constraints and risks
• Biosafety level 2 laboratory
• Routine chemical risks Profil du candidat Savoirs et compétences attendus Training And Experience Required
• Master’s degree in life sciences or equivalent
• Expertise in molecular biology (cloning, PCR, RNA purification, protein purification)
• Expertise in cell culture
• Knowledge of or experience in CRISPR-based methods and/or single-cell RNA-seq Skills Required
• Rigor and scientific integrity
• Ability to work independently
• Perseverance and team spirit Contract information Type of contract: Fixed-term contract Starting date: December 2026-January 2027 Duration: 18 months; renewable once Working time: Full time (218 days/year) Annual Gross

Salary:
from 29240 € to 33013 € according to the current grids

Benefits:
Institute cafeteria, reimbursement of transportation fees up to 70%, supplementary health insurance Location of the position: Paris Contact Please send your CV, letter of motivation and 2 references Publication date: 21/10/2026 Deadline for application: Once filled Faithful to the legacy of its founder, the Institut Curie is deeply committed to promoting equal opportunities, diversity, and inclusion. Convinced that diversity of backgrounds and experiences contributes to collective performance, we strive to provide everyone with a respectful and equitable working environment and encourage all candidates to apply for our job opportunities.
All our opportunities are open to people with disabilities https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf Diplôme et expérience professionnelle Bac+5