Stage M2: The cellular responses to radiation-induced DNA damage during myogenic differentiation H/F

Job DescriptionMissionThe primary objective of this project is to elucidate the mechanisms underlying the cellular responses to radiation-induced DNA damage during myogenic differentiation. This involves investigating the impact of ionizing radiation on the DNA repair processes in myotubes, which are polynuclear cells of skeletal muscle tissue, and comparing...

Project OverviewThe goal of this project is to investigate how myotubes, a type of polynuclear cell found in skeletal muscle tissue, maintain their cellular functions when their nuclei are damaged due to irradiation. This project aims to understand the complex mechanisms of DNA repair and how they impact the genomic integrity of these cells.Research...

MissionCell-to-cell communication is crucial for tissue homeostasis, enabling it to respond to stress, such as irradiation. MicroRNAs (miRNAs) play a key role in this process by regulating gene expression in target cells. The main objective of this internship is to validate preliminary data identifying potential candidate miRNAs found in cell culture...

MissionIntercellular communication is vital for a tissue, enabling it to respond to a stress, such as irradiation, and to restore tissue homeostasis. To this end, cells can use microRNAs (miRNAs) as a communication mean. Their main role is to regulate the expression of certain genes in target cells. The principal objective of this internship is to validate...

Scientific ContextIonizing radiation exposure to the thyroid gland is a recognized risk factor for cancer development, particularly at high doses. However, the impact of low-dose exposure on thyroid organoids remains unclear. To address this knowledge gap, we are seeking a researcher to investigate the effects of ionizing radiation on human thyroid...

\t\tMission\tScientific Context\tThyroid exposure to ionizing radiation (IR) during childhood, following radioactive iodide contamination or external exposure, is a recognized risk factor for the development of cancers, as epidemiology studies have shown. However, the risk decreases with the dose, and the frequency of spontaneous thyroid cancers increases...

MissionScientific contextThyroid exposure to ionizing radiation (IR) during childhood, following radioactive iodide contamination or external exposure is a recognized risk factor for the development of cancers by epidemiology studies, but for thyroid doses above 50mGy. As the risk decreases with the dose and the frequency of spontaneous thyroid cancers...

Scientific ContextExposure to ionizing radiation during childhood is a recognized risk factor for thyroid cancer development. However, the impact of low-dose radiation on thyroid health remains unclear. To address this knowledge gap, we are developing an organoid model of human normal thyroid tissue that reproduces the 3D organization of thyroid...

MissionThe goal of this Masters-2 internship project will be to perform experimental validation of a radiation adverse outcome pathway (AOP-). This goal will be achieved via the following specific tasks: a) analysis of transcriptional profiles (RNA-seq) of cells exposed to ionizing radiation; b) identify altered cellular pathways and biological functions...

Technip Energies - Together, pushing the boundaries to shape a sustainable future Technip Energies is a leading engineering and technology company serving the energy transition, with leading positions in Liquefied Natural Gas (LNG), hydrogen and ethylene and with a strong presence in the growing markets of blue and green hydrogen, sustainable chemistry,...

In the evolving landscape of AI, Attention LSTMs are becoming critical tools for enhancing the explainability of deep learning models. While deep learning approaches, such as LSTMs (Long Short-Term Memory networks), achieve high prognostic performance, they often come with significant computational demands and limited interpretability. Standard feature...

MissionExtending the operational life of Pressurized Water Reactors (PWR) is a significant concern for the nuclear industry in general and for French MWe PWR in particular. Indeed, French MWe PWR operation lifetime initially designed for 40 years is planned to be extended to 60 years, and preliminary studies might suggest an extension up to 80 years. The...

MissionL'objectif principal de ce stage est de caractériser le profil d'expression d'un panel de microARN candidats dans les tissus des membres irradiés et controlatéraux prélevés chez des souris exposées à différentes doses de rayonnements.ObjectifsLa mission consiste à étudier le rôle des microARN dans la réponse tissulaire à l'irradiation...

MissionThe precision and the validity of the neutronic simulations depend directly on the nuclear data used in those simulations. A new nuclear data library, JEFF (Joint Evaluated Fission and Fusion) 4, is planned to be released shortly and an important work of testing and validating this library on experimental data is performed by the scientific community,...

Job OverviewWe are seeking an experienced Product Manager to lead our product development efforts at Central Parking. As a key member of our team, you will be responsible for driving the success of our products and services.About the RoleThe Product Manager will report directly to General Management and act as a liaison between the market and our research...

MissionThe position holder will contribute to the formulation and physicochemical characterisation of emulsions and hydrogels made of hydrophilic or amphiphilic chelating agents at IGPS, and to the assessment of their effectiveness in decontaminating damaged skin or wounds exposed ex vivo to actinides, cesium, or cobalt isotopes using automated Franz...

About Technip Energies :  Technip Energies is a leading engineering and technology company serving the energy transition, with leading positions in Liquefied Natural Gas (LNG), hydrogen and ethylene and with a strong presence in the growing blue and green hydrogen, sustainable chemistry and CO2 management markets. The company benefits from its strong...

Company OverviewIRSN is a leading research organization in the field of nuclear safety and radiation protection. Our mission is to provide scientific expertise and technical assistance to support decision-making processes related to nuclear safety and security.

MissionL'objectif de ce stage de Master 2 consiste à valider expérimentalement un chemin d'effets adverses (AOP) de la radiation. Les tâches spécifiques à atteindre seront : a) l'analyse des profils transcriptionnels (RNA-seq) de cellules exposées à la radiation ionisante ; b) l'identification des voies cellulaires altérées et des...

MissionL'objectif de ce stage de Master 2 sera de valider expérimentalement un chemin d'effet de la radiation (AOP-). Ceci sera réalisé via les tâches spécifiques suivantes : a) analyse des profils transcriptionnels (RNA-seq) de cellules exposées à la radiation ionisante ; b) identifier les voies cellulaires altérées et les fonctions...