Postdoctoral Researcher Or Engineer In Organoid Development H/F
il y a 2 jours
Les missions du poste Le CEA est un acteur majeur de la recherche, au service des citoyens, de l'économie et de l'Etat. Il apporte des solutions concrètes à leurs besoins dans quatre domaines principaux : transition énergétique, transition numérique, technologies pour la médecine du futur, défense et sécurité sur un socle de recherche fondamentale. Le CEA s'engage depuis plus de 75 ans au service de la souveraineté scientifique, technologique et industrielle de la France et de l'Europe pour un présent et un avenir mieux maîtrisés et plus sûrs. Implanté au coeur des territoires équipés de très grandes infrastructures de recherche, le CEA dispose d'un large éventail de partenaires académiques et industriels en France, en Europe et à l'international. Les 20 000 collaboratrices et collaborateurs du CEA partagent trois valeurs fondamentales : La conscience des responsabilités La coopération La curiosité The candidate will be in charge of developing clonal patient-derived organoid (PDO) models from resections. Based on the know‑how of the Biomics and LSMB teams, 3D cell cultures will be produced by clonal development within extracellular matrix microbeads reproducing the physiological microenvironment of the cells. The microbeads are produced semi‑automatically in a dedicated instrument. Your mission will be to develop the protocol for extracting and selecting tumor cells from heterogeneous tumor samples, and to produce the corresponding clonal PDOs in extracellular matrix microbeads. The clonal subpopulations will then be isolated, amplified and characterized on the basis of their genotypes and phenotypes to study the variability of responses of different clonal subpopulations to exposure to pharmaceutical compounds. Your contribution to the team's progress will focus on building up a biobank of characterized PDO models and performing and qualifying compound assays on single and multipatient tumor models. Bibliography: M. E. Dolega et al., Biomaterials, 2015, 52, 347-357. B. Laperrousaz et al., Nucl. Acids Res., 2018, 46, e70. S. Porte et al., Proc. European Organ‑On‑Chips Society (EUROoCS), p. 342, Milano, Italy, 2024. Required work: Extraction and selection of tumor cells from patient samples. Production of clonal tumoroids encapsulated in extracellular matrix microbeads. Sorting, isolation and amplification of clonal subpopulations. Characterization of mutations and phenotypes in each clonal subpopulation. Preservation of patient tumor clones in a biobank.Development of standardized patient tumor models. Toxicological testing of therapeutic compounds and biotherapies on tumor models. Le profil recherché Holder of a Ph.D. in cell biology. You have at least 2 years' professional experience in the field of organoids: development of cell models, 3D cell model responses to compounds. You would like to pursue your career preferably in the private sector. Qualities: organization, rigor, creativity, dynamism, initiative, team spirit. #J-18808-Ljbffr
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Postdoctoral Researcher or Engineer in Organoid Development
il y a 15 heures
Grenoble, France CEA Temps pleinDescription du poste **Domaine**: - Santé **Contrat**: - Post-doctorat **Intitulé de l'offre**: - Postdoctoral researcher or engineer in organoid development H/F **Sujet de stage**: **Durée du contrat (en mois)**: - 18 **Description de l'offre**: resections. Based on the know-how of the Biomics and LSMB teams, 3D cell cultures will be produced by...
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Grenoble, Auvergne-Rhône-Alpes, France CEA Temps pleinInformations générales Entité de rattachement Le CEA est un acteur majeur de la recherche, au service des citoyens, de l'économie et de l'Etat.Il apporte des solutions concrètes à leurs besoins dans quatre domaines principaux : transition énergétique, transition numérique, technologies pour la médecine du futur, défense et sécurité sur un...
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Grenoble, France CEA Temps pleinDescription du poste **Domaine**: - Santé **Contrat**: - CDD **Intitulé de l'offre**: - Engineer or postdoctoral researcher in instrumentation for bioproduction H/F **Statut du poste**: - Cadre **Durée du contrat (en mois)**: - 12 **Description de l'offre**: Based on the microfluidic instruments previously developed in the team, you will design...
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