Engineer or Postdoctoral Researcher in Instrumentation for Bioproduction

il y a 10 heures


Grenoble, France CEA Temps plein

Description du poste

**Domaine**:

- Santé

**Contrat**:

- CDD

**Intitulé de l'offre**:

- Engineer or postdoctoral researcher in instrumentation for bioproduction H/F

**Statut du poste**:

- Cadre

**Durée du contrat (en mois)**:

- 12

**Description de l'offre**:
Based on the microfluidic instruments previously developed in the team, you will design and assemble an encapsulation instrument incorporating functions for automatic counting and transfer of microbeads to the appropriate medium for organoid and tumoroid culture. Your mission will be to adapt the team's previous work and develop a new high-throughput cell encapsulation instrument comprising a microfluidic card, a mechanical holder, pneumatic controllers, temperature control units, optical systems and IT tools. These technical developments will be carried out and validated in collaboration with biologist users.

**Required work**:

- Analysis of requirements and definition of technical specifications to meet them: scale-up + GMP production of organoids and tumoroids
- Design of the optimized functional prototype
- Incorporation of microbead counting and transfer functions
- Validation and qualification of the bioproduction instrument
- Design specifications of the pre-industrial prototype

**Activities**:

- Instrumentation / interfacing
- Dimensioning of the components
- CAD design (SolidWorks) of the instrument including fluid management, thermal management, fluid management (liquids and gases), imaging systems, image processing module.
- Design and production of parts by 3D printing
- Management of subcontracting: supply of components, machining
- Parameterization of components
- Assembly of the equipment
- Functional validation of the developed equipment
- Holder of a Ph.D. or an engineering (MSc) degree with a focus on instrumentation.
- You have at least 2 years of professional experience with a first experience in similar functions.
- You have good skills in system design in microfluidic technologies.
- Qualities: organization, rigor, dynamism, initiative, team spirit

Localisation du poste

**Site**:

- Grenoble

**Localisation du poste**:

- France, Auvergne-Rhône-Alpes, Isère (38)

**Ville**:

- Grenoble

**Formation recommandée**:

- Holder of a Ph.D. or an engineering (MSc) degree with a focus on instrumentation

Demandeur

**Disponibilité du poste**:

- 01/09/2025

Informations générales

**Entité de rattachement**:
Le CEA est un acteur majeur de la recherche, au service des citoyens, de l'économie et de l'Etat.

Il apporte des solutions concrètes à leurs besoins dans quatre domaines principaux : transition énergétique, transition numérique, technologies pour la médecine du futur, défense et sécurité sur un socle de recherche fondamentale. Le CEA s'engage depuis plus de 75 ans au service de la souveraineté scientifique, technologique et industrielle de la France et de l'Europe pour un présent et un avenir mieux maîtrisés et plus sûrs.

Implanté au cœur des territoires équipés de très grandes infrastructures de recherche, le CEA dispose d'un large éventail de partenaires académiques et industriels en France, en Europe et à l'international.

Les 20 000 collaboratrices et collaborateurs du CEA partagent trois valeurs fondamentales:

- La conscience des responsabilités
- La coopération
- La curiosité

**Référence**:2025-36008

**Description de l'unité**:

- L’équipe Biomics, située à l’Institut de Recherche Interdisciplinaire de Grenoble (IRIG) du CEA à Grenoble, produit des organoïdes et des tumoroïdes pour mimer et étudier des architectures et des fonctions physiologiques et pathologiques humaines en collaboration avec le laboratoire « Systèmes microfluidiques et Bio-ingénierie » (LSMB) du Département des Technologies Innovantes en Santé (DTIS) du CEA. Ces équipes sont engagées dans un projet de création d’entreprise dans le domaine des tests de composés sur des modèles cellulaires 3D.



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