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Postdoctoral Researcher in Topical Formulations for Decontamination
il y a 1 mois
Job Description
The position holder will contribute to the development and physicochemical characterization of emulsions and hydrogels containing hydrophilic or amphiphilic chelating agents at IGPS, and to the assessment of their effectiveness in decontaminating damaged skin or wounds exposed ex vivo to actinides, cesium, or cobalt isotopes using automated Franz diffusion cells systems, at IRSN. This includes, but is not limited to:
Key Responsibilities
- Implementing different formulation methods to incorporate chelating agents (HOPO, calixarene, etc...) in pharmaceutical forms that are relevant for topical applications on damaged skin or wounds;
- Characterizing the granulometry (in case of dispersed systems), the rheological properties and the stability of the pharmaceutical forms;
- Performing ex vivo skin diffusion studies of the radioisotopes (U, Pu, Am, Cs, Co) through murine, porcine or human skins using Franz cells with or without decontamination treatments;
- Analyzing the radionuclides in the different compartments and samples using analytical techniques (ICP-MS);
- Analyzing the results of experiments and writing articles for publication in peer-reviewed journals, as well as research reports for internal or external purpose;
- Preparing and presenting talks and poster presentations at internal and external seminars and meetings when requested and approved.
Requirements
- PhD degree in physicochemistry, pharmaceutical technology, pharmacology, biology, chemistry or a relevant discipline from a recognized university;
- Comprehensive background and experience in one or more of the following areas: colloids, (nano)emulsions, hydrogels or dispersed systems formulation and characterisation (rheology, microscopy);
- Experience in skin physiology, radiobiology, radiotoxicology, in vitro skin diffusion study, Franz diffusion cells systems or active ingredients analytical methods will be considered as an asset;
- Demonstrated ability to publish research results as a lead author in peer-reviewed scientific literature;
- Effective communication skills to present results of research as demonstrated by a record of conference or other oral presentations in English;
- Demonstrated high organisation skills, interpersonal skills and ability to work as a part of a multidisciplinary and dynamic team.
Working Conditions
The position holder will be hired by IRSN and the research will be performed partly at IGPS in Orsay and at IRSN in Fontenay-aux-Roses. Occasional trips in France and abroad are expected. The position is eligible for remote work.
IRSN's Commitment to Diversity
IRSN is committed to diversity and inclusion. We strive to create an inclusive work environment that values diversity and promotes equal opportunities for all employees and applicants.
