Muscle Methylation and Metabolism Dynamics

**Muscle methylation and metabolism dynamics - M3 Dynamics**:

- Réf **ABG-131149**
- Sujet de Thèse
- 17/04/2025
- Contrat doctoral
- Institute for Advanced Biosciences, INSERM U1209
- Lieu de travail- Grenoble - Auvergne-Rhône-Alpes - France
- Intitulé du sujet- Muscle methylation and metabolism dynamics - M3 Dynamics
- Champs scientifiques- Biologie
- Santé, médecine humaine, vétérinaire
- Mots clés- muscle homeostasis, cell differentiation, cell signaling, protein methylation

**Description du sujet**:

- The expression of a specific molecular program ruling the right process of muscle stem cells (MuSC) fate is required for regenerative myogenesis and skeletal muscle homeostasis. Muscle pathologies generally originate or result from altered MuSC fate, such as muscle wasting in aging, muscular dystrophy or rhabdomyosarcoma. Covalent post-translational protein modifications (PTMs) such as lysine methylation contribute to all aspects of cell physiology and are a primary source of protein functional diversity in mammalian cells, including muscle biology.
- Our preliminary data suggest that a lysine methyltransferase participates in muscle homeostasis through epigenetic and metabolic signaling. MuSC maintenance and differentiation are controlled by gene expression programs regulated by intertwined epigenetic and metabolic mechanisms and our working hypothesis is that this methyltransferase is a key actor of MuSC fate trajectory by regulating critical epigenetic and metabolic rewiring.
- and metabolic-related functions.
- Altogether, we expect to identify and characterize key relevant protein methylation signaling pathways to provide better insights into muscle biology and therapeutic opportunities for related pathologies of muscle origin.

**Prise de fonction**:

- 06/10/2025

**Nature du financement**:

- Contrat doctoral

**Précisions sur le financement**:
**Présentation établissement et labo d'accueil**:

- Institute for Advanced Biosciences, INSERM U1209

This PhD project will be co-supervised by Dr Reynoird (Institute for Advanced Biosciences, team ProMeDy) and Dr Schlattner (Laboratory of Fundamental and Applied Bioenergetics).

IAB is an internationally renowned research center in basic and translational biomedical research hosting 19 multidisciplinary research teams and groups (300 staff)The goal shared by IAB scientists is Understanding how environment shapes biological systems - that is, the basic mechanisms by which the epigenome, cell and tissue plasticity reprogram themselves under the influence of their chemical, metabolic, physical, cellular, microbiotic and immunological environments. This approach generates both fundamental and translational advances applied to four major global challenges for human health:
Cancer prevention, early detection and experimental therapy

Genetics, epigenetics, physiology and therapies of infertility

Host-pathogen interactions, metabolism and immunity to parasitic infection

Exposome of early life exposures in relation with development and respiratory health.

The team ProMeDy research program, led by Dr Reynoird, focuses on histone-independent protein methylation signaling to explore its non-canonical epigenetic impact on chromatin function and nuclear regulations, as well as in various cytoplasmic processes. Non-histone protein methylation regulates protein function, is highly specific, and dynamically reversible—highlighting its untapped therapeutic potential. However, the full scope of protein methylation signaling remains untapped. The long-term goal of our research is to demonstrate the under-appreciated importance of lysine methylation signaling in cell homeostasis and to offer new promising clinical targets for human diseases, notably cancer.

The LBFA main interest is in regulatory circuits that maintain energetic and metabolic homeostasis, their regulation by life style factors such as nutrition or exercise, and their effects on cell death and survival. The lab aims at better understanding the molecular and cellular mechanisms that allow a cell to maintain its energy state.This depends on “high energy” compounds like ATP and phosphocreatine, in particular the ATP/ADP ratio. Different mechanisms have evolved to cope with fluctuations in energy supply and energy expenditure, as well as intracellular diffusion limitations, which constantly challenge cellular energy homeostasis.

**Site web**:
**Intitulé du doctorat**:

- Doctorat de Biologie

**Pays d'obtention du doctorat**:

- France

**Etablissement délivrant le doctorat**:

- Université Grenoble Alpes

**Ecole doctorale**:

- Chimie et sciences du vivant

**Thèse en cotutelle**:Oui
- **Pays d'obtention du doctorat en cotutelle**:

- France

**Etablissement délivrant le doctorat en cotutelle**:

- Université Grenoble Alpes

French speaking is not required.- 30/05/2025