Internship M2: Integrative Multi-omics for

il y a 3 jours

Bordeaux, France Université de Bordeaux Temps plein

**Internship M2: Integrative Multi-Omics Analysis of Sex-Specific Microglial Mechanisms in Response to Obesity**

Obesity affects 2.1 billion people globally and is the 5th leading cause of death. While it is a widespread epidemic, men are more prone to obesity-related metabolic issues like diabetes, heart attacks, and strokes, whereas women are generally more protected. However, there is limited knowledge on the sex-specific brain response to an obesogenic diet, crucial for developing personalized treatments.

The primary objective of this internship is to integrate multi-omics data to investigate the mechanisms driving sex-dependent microglial responses to a high-calorie diet. This will involve utilizing advanced bioinformatics methodologies to 1) conduct individual omics analyses and 2) integrate these datasets to uncover comprehensive biological insights.
In the first phase, the intern will explore various analytical workflows for omics data processing. This includes standard preprocessing and differential expression analysis for transcriptomics data (using e.g. DESeq2 [Love et al., 2014]), as well as specialized metabolomics analyses, leveraging the Bordeaux bioinformatics lab's (Nikolski lab) expertise with the DIMet tool [Galvis et al., 2024].

**Contacts**

**References**

Love MI, Huber W, Anders S (2014). “Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2.” Genome Biology, 15, 550. doi:10.1186/s13059-014-0550-8.

Hänzelmann S, Castelo R, Guinney, J. (2013). GSVA: gene set variation analysis for microarray and RNA-seq data. BMC bioinformatics, 14, 1-15.

Wieder C, Cooke J, Frainay C, Poupin N, Bowler R, Jourdan F, et al (2024). PathIntegrate: Multivariate modelling approaches for pathway-based multi-omics data integration. PLOS Computational Biology, 20(3), e1011814.

Singh A, Shannon CP, Gautier B, et al. DIABLO: an integrative approach for identifying key molecular drivers from multi-omics assays. Bioinformatics. 2019;35(17):3055-3062. doi:10.1093/bioinformatics/bty1054

**Job Type**: Internship
Contract length: 6 months

Pay: 656.00€ per month

Work Location: In person

Application Deadline: 05/12/2024
Expected Start Date: 02/01/2025

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