Post-doctoral position in Chemical/biology
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Vos missions en quelques mots
Missions :
This project will focus on m6A RNA modification with the objective to explore new RNA modifications to further enhance mRNA vaccine performance.
The post-doctoral position will be divided in three objectives:
1-Develop original chemo-enzymatic methods for site-specific RNA modifications, based on chemoenzymatic strategies and Induced Chemical Proximity (ICP) .
2-Gain deeper insights into the impact of RNA modifications on mRNA-based therapeutics.
3-Apply these methods to the modification of mRNA vaccines.
Activités :
RNA chemistry
Contexte de travail :
Team : « Chemistry of RNAs, Nucleosides, Peptides & Heterocycles”
Laboratoire de Chimie et de Biochimie pharmacologiques et toxicologiques, (LCBPT)
Université Paris Cité.
Profil recherché
Competences :
The candidate with a PhD in organic chemistry should have strong background in organic synthesis, characterization methods (NMR 1D, 2D, and MS) and purification techniques (column chromatography, HPLC). An experience in nucleosides and nucleotides chemistry would be appreciated. The expected qualities of the candidate are a high motivation for research at the interface of chemistry and biology, independency in research work, as well as good written and oral communication skills.
Contraintes et risques :
Classical risks in an organic chemistry laboratory
Niveau d'études minimum requis
- Niveau Niveau 8 Doctorat/diplômes équivalents
- Spécialisation Formations générales
Langues
- Français Seuil
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