CMC Engineer Intern – Polymer Development M/F/X

TISSIUM is a mission-driven medical device company founded in 2013, headquartered in Paris, with a production facility in Roncq (near Lille) and an office in Boston. We are dedicated to creating a new era of body repair by leveraging our biopolymer platform to develop innovative solutions in surgery for a positive impact on patients' lives. TISSIUM's technology is based on research and intellectual property from the laboratories of Professor Robert Langer (MIT) and Professor Jeffrey M. Karp (Brigham and Women's Hospital), who co-founded the company with Christophe Bancel (CEO) and Maria Pereira (Deputy CEO & Chief Innovation Officer). We develop polymers for atraumatic tissue repair. Today, they are used for sutureless nerve repair, hernia repair and cardiovascular sealing. Since our inception, we have raised a total of 170 million euros, including 50 million euros in our latest round (April 2023), to finance the commercialization of our first products. YOUR MISSION As part of your end-of-studies internship, you will join Tissium’s CMC (Chemistry, Manufacturing & Controls) team in Paris for 6 months, starting january/february, reporting to a Senior CMC Engineer. The CMC Team Develops The Polymers At The Heart Of Our Medical Devices. You Will Contribute To Every Stage Of Their Development
• deepening our understanding of their structure and physico-chemical properties
• designing and optimizing manufacturing processes
• running the studies that demonstrate their safety and performance The internship includes a significant share of hands-on lab work, alongside interactions with our external partners and subcontractors. Responsibilities In the lab
• Perform the experimental work supporting the development of Tissium polymers: chemical reactions, purifications, analytics, performance testing
• Help design, perform and follow key testing methods to support the safety and performance of our polymers
• Analyze your results and report on them Process development
• Support the setup and management of process design and optimization activities, through scale-up and transfer to production, internally or with subcontractors
• Help plan and follow up on subcontracted activities: feasibility and optimization work, production planning, batch reviews Verification, validation & documentation
• Contribute to the design, planning and follow-up of key verification and validation studies (e.g. stability studies, in vitro degradation studies)
• Support the team in writing and reviewing CMC documentation for Tissium products
• Work in line with Tissium’s Quality Management System and applicable regulatory requirements

YOUR PROFILE
Required
• Final-year engineering student or equivalent, with a background in chemistry, process development and/or analytics
• First hands-on lab experience (internship or project): basic synthesis and purification techniques, use of standard analytical equipment, data analysis and reporting
• Professional proficiency in English, written and spoken Nice to have
• Knowledge of polymers and/or materials science You are autonomous and well organized, with strong planning and problem-solving skills. You approach technical challenges creatively and are comfortable understanding complex processes involving several partners. You are a team player and eager to learn. WHY JOIN US
• A hands-on, end-to-end internship: from the lab bench to production and validation studies, you will see the full development cycle of a medical-grade polymer
• Meaningful impact: our polymers are used for sutureless nerve repair, hernia repair and cardiovascular sealing
• Real mentoring: day-to-day supervision by a senior engineer of the CMC team
• An international environment: 19+ nationalities, with teams in Paris, Roncq and Boston
• Internship allowance and

benefits:
[monthly amount] [+ meal vouchers, transport reimbursement…] PRACTICAL INFORMATION
• End-of-studies internship (internship agreement required)
• Duration: 6 months, starting in january/february
•

Location:
Paris RECRUITMENT PROCESS
• HR video interview (30 min)
• Video interview with the manager (1h)
• On-site meeting with the team Fondée en 2013, Tissium est une entreprise dynamique spécialisée dans les dispositifs médicaux qui se consacre au développement de solutions innovantes pour la reconstruction tissulaire. Nous exploitons nos plateformes technologiques pour développer de nouvelles solutions innovantes en chirurgie afin d'améliorer la vie des patients. Notre siège social est situé à Paris, nous disposons d'un site de production à Roncq (près de Lille) et d'un bureau à Boston.