Postdoctoral Researcher in Vascular Mechanobiology
il y a 2 semaines
Job Environment:
Institut Mines-Télécom is a leading public group of engineering and management Grandes Écoles in France, consisting of eight public graduate schools and two subsidiary graduate schools. It leads and develops a rich ecosystem of partner schools, economic, academic, and institutional partners, key players in education, research, and economic development.
Mines Saint-Étienne, a graduate school of the Institut Mines-Télécom, is responsible for education, research, innovation, industrial transfer, and scientific culture dissemination. With 2,500 students, 500 staff, and a budget of €50m, it has three campuses dedicated to the industry of the future, health and well-being, and digital sovereignty and microelectronics. It is ranked in the top 15 graduate engineering schools in France and the top 500 universities worldwide.
The 2023-2027 strategy of Mines Saint-Etienne is in line with that of Institut Mines Telecom. It aims to:
- Support the ecological, digital, and generational transitions and educate the people involved
- Support national and European sovereignty in microelectronics and digital technology
To support this strategy, it is recruiting a postdoctoral researcher.
Job Description:
The Centre Ingénierie et Santé (CIS) brings together 70 people, including 18 professors in engineering, industrial/computing, biomechanics, and healthcare engineering. Since its creation in 2004, the CIS has been representative of the ability of Mines Saint-Etienne to acquire leadership on innovative themes such as soft tissue biomechanics.
SAINBIOSE (INSERM UMR 1059) brings together researchers from the CIS (biomechanics, biomaterials, and bioengineering), the faculty of Medicine from Jean Monnet University, Saint-Etienne University Hospital, Inserm, and the French Blood Establishment. The global scientific objective of SAINBIOSE is a better understanding and of biostress in osteoarticular (LBTO team) and cardiovascular pathology (DVH team).
Biomechanics, experimental and computational, is a major research topic of SAINBIOSE, which goes from modelling the mechanical behaviour of tissues to clinical and industrial applications, especially with the textile industry. In 2024, Prof Stéphane Avril was awarded an ERC Advanced grant from the European Research Council for the project JuvenTwin "Multiscale mechanobiological synergies in vascular homeostasis, ageing and rejuvenation", which aims to establish multiscale digital twins of ageing effects on vascular mechanobiology and to simulate and screen effective rejuvenation treatments.
This project will take place in a research group having 15 years experience in biomechanics and mechanobiology.
We open a non-permanent position of postdoctoral fellow to join the Avril's team working on a project funded by Manutech-Sleight Graduate School. The work will be carried out at Mines Saint-Etienne, within the SAINBIOSE research unit (Inserm U1059). It is based at the Centre Ingénierie et Santé (Hospital campus at the North of Saint-Etienne).
The objective of the postdoctoral fellow will be to map the mechanical stimuli around vascular smooth muscle cells in collagen hydrogels, including strain gradients, strains, and stresses, and correlate them to specific local phenotypic parameters. For this, we propose to engrave micromarkers around cells in collagen hydrogels by densification thanks to the femtosecond laser, then to precisely follow the position of these markers in confocal microscopy at first (microscopic resolution), then in-line holography in a second step (nanometric resolution).
These precise and real-time measurements will be employed to develop a machine learning model of the mechanical interactions between the cell and its environment, with major potential applications for the diagnosis of cancers or cardiovascular diseases.
Tasks may change depending on the needs of the department and Mines Saint-Etienne.
Profile Sought:
You are in one of the following situations:
- A doctoral degree no more than 3 years old, in which case you will be employed as a postdoctoral researcher
- If your doctorate is more than 3 years old, you will be employed as a research and development engineer
And ideally:
- Holder of PhD degree in biomechanics
You have the following skills, knowledge, and experience:
- Capacity to successfully integrate a team and a group within a R&D environment
- Good knowledge of basic cell biology, biomaterials
- First experience with testing vascular cells and/or blood vessels
- Expertise in front-end and back-end development
Why Join Us:
Institut Mines-Telecom is characterised by:
- A scientific environment of excellence
- A group with entities throughout France
Mines Saint-Etienne is distinguished by:
- A privileged working environment with a high student supervision rate and a high environment rate (support and back-up functions)
- First-rate experimental and digital resources
- Significant contract research activity (€11m/year in Research and Innovation contracts), mainly with industrial partners
- 25% international students, Member of the T.I.M.E. network and the EULIST European University
- A centre for scientific, technical, and industrial culture - La Rotonde - which is unique in France, and which has a major impact on society (> 50,000 visitors per year)
- Pleasant workplace, easily accessible by public transport and close to motorways
- Public transport costs reimbursed up to 75% (subject to conditions)
- Sustainable mobility package
- Staff committee that subsidises sports, leisure, cultural, and social events and activities
- The possibility of partial remote working
- 49 days annual leave
Additional Information:
Recruitment conditions:
- Fixed-term contract for a period of 12 months (renewable)
- Desired start date: 1st October 2024
- Remuneration will be set according to the candidate's profile, based on the rules defined by the Institut Mines Télécom's management framework
- Full time
- Position based in Saint-Étienne
- For internal use:
- Category II - Job P - Post doctorant according to the Management Framework
The position is open to all, with accommodation available on request for candidates with disabilities. The job is open to civil servants and/or the general public. All applications may be subject to an administrative enquiry.
How to apply:
Applications (CV, covering letter, letter of recommendation if applicable) must be submitted on the RECRUITEE platform no later than 15/08/2024:
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St Étienne, Auvergne-Rhône-Alpes, France Institut Mines-Télécom Temps pleinJob Environment:Institut Mines-Télécom is a leading public group of engineering and management Grandes Écoles in France, consisting of eight public graduate Grandes Écoles and two subsidiary graduate schools. The group leads and develops a rich ecosystem of partner schools, economic, academic, and institutional partners, key players in education,...
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St Étienne, Auvergne-Rhône-Alpes, France Institut Mines-Télécom Temps pleinJob EnvironmentInstitut Mines-Télécom is a leading public group of engineering and management Grandes Écoles in France, consisting of eight public graduate schools and two subsidiary graduate schools. The group leads and develops a rich ecosystem of partner schools, economic, academic, and institutional partners, key players in education, research, and...
