Analysis of Human Normal Thyroid Organoids Response to Ionizing Radiation Specialist
il y a 3 semaines
Mission
Scientific Context
Thyroid exposure to ionizing radiation during childhood is a recognized risk factor for the development of cancers. However, the risk decreases with the dose, and statistical epidemiological methods are no longer applicable. To address this knowledge gap, we are developing an organoid model derived from human normal thyroid tissue, reproducing the 3D organization of thyroid follicles. The candidate will be involved in the analysis of the organoids' response to low doses of ionizing radiation.
Work Context and Objectives
We have culture conditions that permit to maintain follicular 3D structure, which synthesize the thyroid hormone thyroxine in the lumen. The candidate will be responsible for developing protocols focused on the analysis of the oxidative status of the organoids after exposure, including exploration of key signaling pathways, mitochondrial function, and reactive oxygen species production. This will be achieved in collaboration with the laboratory of T. Pourcher.
Long-Term Maintenance of Thyrospheres
The candidate will also be involved in the long-term maintenance of thyrospheres in culture, with the objective of following the response to ionizing radiation over the longest culture period. This will enable the analysis of possibly the early steps of carcinogenesis. The culture process should maintain the organoids' 3D structure and physiology over time.
Required Profile
Applicants should have a PhD in molecular and cellular biology. A good experience in cell culture and knowledge of the molecular mechanisms of the cellular response to genotoxic stress will be appreciated. The selected candidate will be encouraged to present the findings of the project at scientific conferences and to administrative authorities.
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Nanterre, Île-de-France IRSN Temps pleinJob DescriptionScientific ContextIonizing radiation exposure to the thyroid gland during childhood has been identified as a risk factor for cancer development. However, the impact of low-dose exposure on public health remains unclear. To address this knowledge gap, we are developing an organoid model of human normal thyroid tissue, which reproduces the 3D...
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Investigation of Thyroid Organoids Response to Ionizing Radiation
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Nanterre, Île-de-France IRSN Temps pleinScientific ContextIonizing radiation exposure to the thyroid gland is a recognized risk factor for cancer development, particularly at high doses. However, the impact of low-dose exposure on thyroid organoids remains unclear. To address this knowledge gap, we are seeking a researcher to investigate the effects of ionizing radiation on human thyroid...
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Thyroid Organoid Radiation Response Analyst
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Nanterre, Île-de-France IRSN Temps pleinJob Title: Analysis of Human Normal Thyroid Organoids Response to Ionizing RadiationJob Summary:We are seeking a highly motivated and experienced researcher to join our team at the Institute for Radiological Protection and Nuclear Safety (IRSN) in France. The successful candidate will be responsible for analyzing the response of human normal thyroid...
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Nanterre, Île-de-France IRSN Temps pleinMissionScientific contextExposure to ionizing radiation (IR) during childhood is a recognized risk factor for the development of cancers. However, the impact of low doses on public health remains unclear. To address this question, we are developing an organoid model of human normal thyroid tissue, which reproduces the 3D organization of thyroid follicles and...
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Nanterre, Île-de-France IRSN Temps pleinScientific ContextExposure to ionizing radiation during childhood is a recognized risk factor for thyroid cancer development. However, the impact of low-dose radiation on thyroid health remains unclear. To address this knowledge gap, we are developing an organoid model of human normal thyroid tissue that reproduces the 3D organization of thyroid...
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Nanterre, Île-de-France IRSN Temps pleinMissionScientific contextExposure to ionizing radiation during childhood is a recognized risk factor for thyroid cancer development. However, the impact of low doses on public health remains unclear. To address this question, we are developing an organoid model of human normal thyroid tissue, which reproduces the 3D organization of thyroid follicles and...
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Nanterre, Île-de-France IRSN Temps plein\t\tMission\tScientific Context\tThyroid exposure to ionizing radiation (IR) during childhood, following radioactive iodide contamination or external exposure, is a recognized risk factor for the development of cancers, as epidemiology studies have shown. However, the risk decreases with the dose, and the frequency of spontaneous thyroid cancers increases...
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