Emplois actuels liés à Biologist Researcher: Cellular Responses to Radiation-Induced DNA Damage - Nanterre, Île-de-France - IRSN
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Nanterre, Île-de-France IRSN Temps pleinProject OverviewThe goal of this project is to investigate how myotubes, a type of polynuclear cell found in skeletal muscle tissue, maintain their cellular functions when their nuclei are damaged due to irradiation. This project aims to understand the complex mechanisms of DNA repair and how they impact the genomic integrity of these cells.Research...
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Investigation of Thyroid Organoids Response to Ionizing Radiation
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Nanterre, Île-de-France IRSN Temps pleinJob DescriptionThe postdoctoral researcher will contribute to the formulation and physicochemical characterization of emulsions and hydrogels made of hydrophilic or amphiphilic chelating agents at IGPS, and to the assessment of their effectiveness in decontaminating damaged skin or wounds exposed ex vivo to actinides, cesium, or cobalt isotopes using...
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Nanterre, Île-de-France Technip Energies Temps pleinAbout this opportunity:Techip Energies is a leading engineering and technology company in the energy transition. We are seeking an ambitious and detail-oriented individual to join our Market team in the Decarbonization Solutions Business Line.Your main focus will be on analyzing the carbon capture market, focusing on power generation and industrial sectors...
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Nanterre, France IRSN Temps pleinMissionThe goal of this project is to understand how myotubes, polynuclear cells of skeletal muscle tissue, in comparison to its mono-nuclear precursors, myoblasts, maintain their cellular functions when one or more of their nuclei are damaged upon irradiation. Interaction of ionizing radiation with living matter induces various types of damage, particularly...
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Nanterre, France IRSN Temps pleinMissionScientific contextThyroid exposure to ionizing radiation (IR) during childhood, following radioactive iodide contamination or external exposure is a recognized risk factor for the development of cancers by epidemiology studies, but for thyroid doses above 50mGy. As the risk decreases with the dose and the frequency of spontaneous thyroid cancers...
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Nanterre, France IRSN Temps pleinMissionIntercellular communication is vital for a tissue, enabling it to respond to a stress, such as irradiation, and to restore tissue homeostasis. To this end, cells can use microRNAs (miRNAs) as a communication mean. Their main role is to regulate the expression of certain genes in target cells. The principal objective of this internship is to validate...
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Stage de Master 2
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Nanterre, France IRSN Temps pleinMissionThe position holder will contribute to the formulation and physicochemical characterisation of emulsions and hydrogels made of hydrophilic or amphiphilic chelating agents at IGPS, and to the assessment of their effectiveness in decontaminating damaged skin or wounds exposed ex vivo to actinides, cesium, or cobalt isotopes using automated Franz...
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Nanterre, France IRSN Temps pleinMissionExtending the operational life of Pressurized Water Reactors (PWR) is a significant concern for the nuclear industry in general and for French MWe PWR in particular. Indeed, French MWe PWR operation lifetime initially designed for 40 years is planned to be extended to 60 years, and preliminary studies might suggest an extension up to 80 years. The...
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Biologist Researcher: Cellular Responses to Radiation-Induced DNA Damage
Il y a 2 mois
Mission
The primary objective of this project is to elucidate the mechanisms underlying the cellular responses to radiation-induced DNA damage during myogenic differentiation. This involves investigating the impact of ionizing radiation on the DNA repair processes in myotubes, which are polynuclear cells of skeletal muscle tissue, and comparing them to their mono-nuclear precursors, myoblasts.
Key Responsibilities
- Develop an in vitro myogenic differentiation model to generate multi-nucleated and post-mitotic myotubes with ectopic expression of DNA repair proteins of interest coupled to GFP.
- Use a microscopy integrated system to induce local DNA lesions within one or more myonuclei and evaluate the treatment with specific DNA repair and cellular communication inhibitors.
- Assay the survival of different myogenic cells upon irradiation at different doses using MTT assay and analyze the dynamic behavior of GFP-tagged DNA repair proteins using real-time imaging techniques.
Requirements
- Highly motivated M2 student in biology/health sciences with good knowledge in cellular and molecular biology.
- Strong inclination for microscopy and experience with immunofluorescence and confocal microscopy techniques.
- Ability to work independently and as part of a team.
Working Conditions
This internship will be conducted on-site at IRSN's premises in France.
IRSN's Commitment to Diversity
IRSN is committed to promoting diversity and inclusion in the workplace. We welcome applications from candidates with diverse backgrounds and abilities and strive to create an inclusive environment that values and respects all employees.
